Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49244
Title: Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw
Authors: Bocanegra-Pérez, S.
Vicente-Barrero, M. 
Knezevic, M.
Castellano-Navarro, J. M.
Rodríguez-Bocanegra, E.
Rodríguez-Millares, J.
Pérez-Plasencia, D.
Ramos-Macías, A.
Keywords: Avascular Osteonecrosis
Bone Resection
Necrosis
Issue Date: 2012
Publisher: 0901-5027
Journal: International Journal of Oral and Maxillofacial Surgery 
Abstract: Platelet-rich plasma is a concentrate of growth factors and osteoconductive proteins, which can play a major role in bone biology by accelerating and enhancing bone repair and regeneration. This paper describes the results of using platelet-rich plasma in the management of bisphosphonate-associated necrosis of the jaw. Eight patients with a diagnosis of bisphosphonate-associated necrosis of the jaw were surgically treated for debridement and removal of necrotic bone, followed by application of autologous platelet concentrate enriched with growth factors and primary suture of the wound. Patients underwent periodic clinical and radiological follow-up examinations. All patients showed clinical improvement and oral lesions resolved 2-4 weeks after treatment. After an average 14-month follow up period, patients remained asymptomatic. Although not conclusive, the combination of necrotic-bone curettage and platelet-rich-plasma to treat refractory osteonecrosis of the jaw yielded promising results.
URI: http://hdl.handle.net/10553/49244
ISSN: 0901-5027
DOI: 10.1016/j.ijom.2012.04.020
Source: International Journal of Oral and Maxillofacial Surgery[ISSN 0901-5027],v. 41, p. 1410-1415
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