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Title: Are the Spanish baseline series markers sufficient to detect contact allergy to corticosteroids in Spain? A GEIDAC prospective study
Authors: Mercader-García, Pedro
Pastor-Nieto, María A.
García-Doval, Ignacio
Giménez-Arnau, Ana
González-Pérez, Ricardo
Fernández-Redondo, Virginia
Serra-Baldrich, Ester
Cordoba-Guijarro, Susana
Gatica-Ortega, María E.
Silvestre-Salvador, Juan F.
Armario-Hita, José Carlos
Borrego-Hernando, Leopoldo 
Carrascosa-Carrillo, José Manuel
Córdoba-Guijarro, Susana
Diaz-Ley, Blanca
García-Bravo, Begoña
Gatica-Ortega, María Elena
Giménez-Arnau, Ana María
Gómez de la Fuente, Enrique
Guimaraens, Dolores
Hervella-Garcés, Marcos
Ortiz de Frutos, Javier
Pastor-Nieto, María Antonia
Rodríguez-Serna, Mercedes
Ruíz-González, Inmaculada
Sánchez-Pedreño, Paloma
Sánchez-Pérez, Javier
Silvestre, Juan Francisco
Serra-Baldrich, Esther
UNESCO Clasification: 32 Ciencias médicas
320106 Dermatología
Keywords: Budesonide
Contact allergy
Hydrocortisone 17-butyrate
Topical corticosteroids
Issue Date: 2017
Journal: Contact Dermatitis 
Abstract: Background Corticosteroids are among the most commonly used topical drugs. Contact allergy to these exists, but can be easily missed. Corticosteroid screening markers have been included in the baseline series with the aim of detecting most of the sensitized patients. Objectives To assess the prevalence of contact allergy to topical corticosteroids in Spain and examine the usefulness of corticosteroid markers to detect contact allergy to corticosteroids. Methods In total, 3699 patients referred to 20 dermatology departments across Spain for patch testing with the baseline series, including budesonide and tixocortol pivalate, were also tested with six supplementary corticosteroids (methylprednisolone aceponate, mometasone furoate, prednicarbate, clobetasol propionate, betamethasone 17-valerate, and betamethasone 17,21-dipropionate). Additionally, 2547 (68.8%) patients were tested with hydrocortisone 17-butyrate. Results Fifty-four patients showed positive reactions to at least one of all tested corticosteroids (1.46%). Thirty-nine (1.05%) reacted to at least one of the additionally tested corticosteroids; among these, 24 of 39 (61.5%) did not react to any of the corticosteroid allergy screening markers tested. Conclusions More than half of the patients who were allergic to the additionally tested corticosteroids were not detected with the corticosteroid allergy markers. An update of the corticosteroid allergy screening markers is encouraged, with consideration of group 3 corticosteroids.
ISSN: 0105-1873
DOI: 10.1111/cod.12874
Source: Contact Dermatitis[ISSN 0105-1873],v. 78, p. 76-82 (Septiembre 2017)
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