Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49068
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dc.contributor.authorDerom, Marie Laure
dc.contributor.authorMartínez-González, Miguel Á
dc.contributor.authorSayón-Orea, Maria Del Carmen
dc.contributor.authorBes-Rastrollo, Maira
dc.contributor.authorBeunza, Juan J.
dc.contributor.authorSánchez-Villegas, Almudena
dc.date.accessioned2018-11-24T03:43:34Z-
dc.date.available2018-11-24T03:43:34Z-
dc.date.issued2012
dc.identifier.issn0022-3166
dc.identifier.urihttp://hdl.handle.net/10553/49068-
dc.description.abstractMagnesium is the second most predominant intracellular cation and it is an important cofactor in over 300 enzymatic reactions. It is a calcium antagonist and a voltage-dependant blocker of the N-methyl-D-aspartate channel, which plays a role in the entrance of calcium into the neuron. Other mechanisms also add biological plausibility to neuro-protective properties for magnesium, including an inverse association with major depression. A higher magnesium intake has been related to lower depressive symptoms. However, epidemiological evidence on this issue is scarce. Our aim was to prospectively evaluate the association between dietary magnesium intake and depression incidence in a cohort of 12,939 Spanish university graduates initially free of depression (Seguimiento Universidad de Navarra Cohort Study). Total magnesium intake was assessed with a validated, semiquantitative FFQ and incident depression was ascertained through self-reports of a new clinical diagnosis of depression done by a medical doctor and/or the habitual use of antidepressive drugs. The self-report was validated against the Diagnostic and Statistical Manual of Mental Disorders (4th edition) criteria in a subsample of the cohort. Cox regression models were used to obtain HR of incident depression during follow-up according to baseline quintiles of magnesium intake using the lowest quintile as the reference category. After a median follow-up of 6.3 y, 737 new cases of depression were identified. No association between magnesium intake and depression was found, with multivariate-adjusted HR = 1 (reference), 1.00 (95% CI: 0.78-1.27), 1.00 (0.76-1.31), 0.95 (0.70-1.30), and 1.11 (0.77-1.59) for increasing categories (quintiles 1-5) of total magnesium intake. No dose-response relationship was found (P-trend = 0.59). Results were robust through different sensitivity analyses, including nutrient density or residual models. In conclusion, our findings do not suggest an inverse association between magnesium intake and depressive disorder. J. Nutr. 142: 1053-1059, 2012.
dc.publisher0022-3166
dc.relation.ispartofJournal of Nutrition
dc.sourceJournal of Nutrition[ISSN 0022-3166],v. 142, p. 1053-1059
dc.subject.otherFood-Frequency Questionnaire
dc.subject.otherMediterranean Diet
dc.subject.otherFish Consumption
dc.subject.otherAssociation
dc.subject.otherSymptoms
dc.subject.otherAnxiety
dc.subject.otherFolate
dc.subject.otherSupplementation
dc.subject.otherVitamin-B-12
dc.subject.otherPopulation
dc.titlemagnesium intake is not related to depression risk in Spanish university graduates
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.3945/jn.111.155572
dc.identifier.scopus84863549063
dc.identifier.isi000304335500012
dc.contributor.authorscopusid55301191600
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid36661328600
dc.contributor.authorscopusid56247740200
dc.contributor.authorscopusid8866000700
dc.contributor.authorscopusid6602876903
dc.description.lastpage1059
dc.description.firstpage1053
dc.relation.volume142
dc.type2Artículoes
dc.contributor.daisngid12665456
dc.contributor.daisngid17754
dc.contributor.daisngid1076089
dc.contributor.daisngid154711
dc.contributor.daisngid30344543
dc.contributor.daisngid289030
dc.contributor.wosstandardWOS:Derom, ML
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Sayon-Orea, MD
dc.contributor.wosstandardWOS:Bes-Rastrollo, M
dc.contributor.wosstandardWOS:Beunza, JJ
dc.contributor.wosstandardWOS:Sanchez-Villegas, A
dc.date.coverdateJunio 2012
dc.identifier.ulpgces
dc.description.sjr1,919
dc.description.jcr4,196
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.orcid0000-0001-7733-9238-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSánchez Villegas, Almudena-
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