Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/49068
Campo DC Valoridioma
dc.contributor.authorDerom, Marie Laureen_US
dc.contributor.authorMartínez-González, Miguel Áen_US
dc.contributor.authorSayón-Orea, Maria Del Carmenen_US
dc.contributor.authorBes-Rastrollo, Mairaen_US
dc.contributor.authorBeunza, Juan J.en_US
dc.contributor.authorSánchez-Villegas, Almudenaen_US
dc.date.accessioned2018-11-24T03:43:34Z-
dc.date.available2018-11-24T03:43:34Z-
dc.date.issued2012en_US
dc.identifier.issn0022-3166en_US
dc.identifier.urihttp://hdl.handle.net/10553/49068-
dc.description.abstractMagnesium is the second most predominant intracellular cation and it is an important cofactor in over 300 enzymatic reactions. It is a calcium antagonist and a voltage-dependant blocker of the N-methyl-D-aspartate channel, which plays a role in the entrance of calcium into the neuron. Other mechanisms also add biological plausibility to neuro-protective properties for magnesium, including an inverse association with major depression. A higher magnesium intake has been related to lower depressive symptoms. However, epidemiological evidence on this issue is scarce. Our aim was to prospectively evaluate the association between dietary magnesium intake and depression incidence in a cohort of 12,939 Spanish university graduates initially free of depression (Seguimiento Universidad de Navarra Cohort Study). Total magnesium intake was assessed with a validated, semiquantitative FFQ and incident depression was ascertained through self-reports of a new clinical diagnosis of depression done by a medical doctor and/or the habitual use of antidepressive drugs. The self-report was validated against the Diagnostic and Statistical Manual of Mental Disorders (4th edition) criteria in a subsample of the cohort. Cox regression models were used to obtain HR of incident depression during follow-up according to baseline quintiles of magnesium intake using the lowest quintile as the reference category. After a median follow-up of 6.3 y, 737 new cases of depression were identified. No association between magnesium intake and depression was found, with multivariate-adjusted HR = 1 (reference), 1.00 (95% CI: 0.78-1.27), 1.00 (0.76-1.31), 0.95 (0.70-1.30), and 1.11 (0.77-1.59) for increasing categories (quintiles 1-5) of total magnesium intake. No dose-response relationship was found (P-trend = 0.59). Results were robust through different sensitivity analyses, including nutrient density or residual models. In conclusion, our findings do not suggest an inverse association between magnesium intake and depressive disorder.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Nutritionen_US
dc.sourceJournal of Nutrition[ISSN 0022-3166],v. 142, p. 1053-1059 (Junio 2012)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherFood-Frequency Questionnaireen_US
dc.subject.otherMediterranean Dieten_US
dc.subject.otherFish Consumptionen_US
dc.subject.otherAssociationen_US
dc.subject.otherSymptomsen_US
dc.subject.otherAnxietyen_US
dc.subject.otherFolateen_US
dc.subject.otherSupplementationen_US
dc.subject.otherVitamin-B-12en_US
dc.subject.otherPopulationen_US
dc.titleMagnesium intake is not related to depression risk in Spanish university graduatesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3945/jn.111.155572en_US
dc.identifier.scopus84863549063-
dc.identifier.isi000304335500012-
dc.contributor.authorscopusid55301191600-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid36661328600-
dc.contributor.authorscopusid56247740200-
dc.contributor.authorscopusid8866000700-
dc.contributor.authorscopusid6602876903-
dc.description.lastpage1059en_US
dc.description.firstpage1053en_US
dc.relation.volume142en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid12665456-
dc.contributor.daisngid17754-
dc.contributor.daisngid1076089-
dc.contributor.daisngid154711-
dc.contributor.daisngid30344543-
dc.contributor.daisngid289030-
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Derom, ML-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.contributor.wosstandardWOS:Sayon-Orea, MD-
dc.contributor.wosstandardWOS:Bes-Rastrollo, M-
dc.contributor.wosstandardWOS:Beunza, JJ-
dc.contributor.wosstandardWOS:Sanchez-Villegas, A-
dc.date.coverdateJunio 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,919-
dc.description.jcr4,196-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0001-7733-9238-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSánchez Villegas,Almudena-
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