Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48740
Title: Ultrastructural analogies between intimal alterations in veins from diabetic patients and animals with STZ-induced diabetes
Authors: Mompeo, B 
Ortega, Francisco 
Sarmiento, Lourdes
Castaño, Irene
UNESCO Clasification: 32 Ciencias médicas
321317 Cirugía vascular
Keywords: Endothelial-Cells
Graft Stenosis
Smooth-Muscle
Disease
Progression, et al
Issue Date: 1999
Journal: Annals of Vascular Surgery 
Abstract: The aim of this study was to document similarities and differences between veins from human diabetic patients and an experimentally induced diabetic animal model. The sapheneous vein and posterior tibial vein from diabetic patients and the femoral vein from rats were studied. An increase in the extracellular matrix with migration of smooth muscle cells and endothelial alterations were observed in the intima of all specimens. These findings demonstrate that there is a high degree of similarity between the pathological changes in the venous wall during human diabetes mellitus and streptozotocin (STZ) induced-diabetes. This finding validates STZ induced-diabetes in rats as a model for further experimental study to clarify the fate of the diabetic venous wall when used as a graft.
URI: http://hdl.handle.net/10553/48740
ISSN: 0890-5096
DOI: 10.1007/s100169900260
Source: Annals Of Vascular Surgery[ISSN 0890-5096],v. 13 (3), p. 294-301
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