Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48739
Title: Immunohistochemical and ultrastructural study of microvessels in diabetic veins
Authors: Mompeo, B 
Ortega, Francisco 
Keywords: Endothelial Growth-Factor
Angiogenesis
Atherosclerosis
Expression
Mellitus
Issue Date: 1999
Publisher: 0191-3123
Journal: Ultrastructural Pathology 
Abstract: The aim of this study was to examine the localization and features of the intramural microvessels in the wall of inferior limb veins in diabetic patients. The study was conducted in a group of 10 insulin-dependent diabetic patients, who had suffered inferior limb amputation as a consequence of chronic limb ischemia. Sections of long saphenous and posterior tibial veins were investigated by light and transmission electron microscope. The von Willebrand factor and albumin were detected by immunohistochemical techniques. The results show the presence of numerous microvessels in the intima and inner third of the media layer of the venous wall of the sections studied. These microvessels present morphological and functional modifications in relation to those observed in the control veins. They also showed the presence of endothelial cells migrating from the lumen. The authors conclude that the Venous wall of inferior limbs in amputated diabetic patients presents a neovascularization process. Some of the endothelial cells of the venous lumen can also have a role in the angiogenesis.
URI: http://hdl.handle.net/10553/48739
ISSN: 0191-3123
DOI: 10.1080/019131299281806
Source: Ultrastructural Pathology[ISSN 0191-3123],v. 23 (1), p. 25-31
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