Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48714
Campo DC Valoridioma
dc.contributor.authorBoada, Luis D.en_US
dc.contributor.authorZumbado, Manuelen_US
dc.contributor.authorDel Río, Isidoroen_US
dc.contributor.authorBlanco, Alfonsoen_US
dc.contributor.authorTorres, Santiagoen_US
dc.contributor.authorMonterde, José G.en_US
dc.contributor.authorAfonso, Juan L.en_US
dc.contributor.authorCabrera, Juan J.en_US
dc.contributor.authorDíaz-Chico, Bonifacio N.en_US
dc.contributor.otherZumbado, Manuel-
dc.contributor.otherDominguez-Boada, Luis-
dc.contributor.otherCabrera-Galvan, Juan Jose-
dc.date.accessioned2018-11-24T00:17:55Z-
dc.date.available2018-11-24T00:17:55Z-
dc.date.issued2002en_US
dc.identifier.issn0340-5761en_US
dc.identifier.urihttp://hdl.handle.net/10553/48714-
dc.description.abstractThe aim of this study was to evaluate the acute hepatic effects exerted by the steroid hormone progesterone (PR) in the rat. Although the liver is not a target tissue for this hormone, a number of hepatic actions of PR have been described, and, furthermore, a specific binding site for PR (PBS) exists in rat liver microsomes. Immature male rats were treated intraperitoneally with 60 mg/kg PR per day for 1, 5 or 10 days, and different parameters were evaluated in order to detect possible alterations in liver cells. Morphological study of the livers did not present images of cytotoxicity in any group of animals. The presence of a clear hyperplasia of smooth endoplasmic reticulum (SER) was noteworthy, mainly seen in perilobular hepatocytes. Despite this SER increase, the levels of cytochrome P450 (Cyt P450) significantly decreased after 10 days of PR administration. Similarly, the concentration of PBS was significantly decreased after 10 days of treatment with PR. On the other hand, these studies revealed a clear increase of mitotic activity and Ki-67 labelling index in the livers of animals treated with PR; furthermore, livers of PR-treated animals showed an increased percentage of binucleate hepatocytes. Flow cytometry analysis showed that although ploidy status of liver cells was not modified in any case the percentage of diploid nuclei in S-phase decreased during treatment with PR. The most relevant finding was the presence of abnormal mitosis and c-mitosis in livers from animals from all PR-treated groups. This study demonstrates that PR (a) does not induce cytotoxicity although it can induce cell proliferation and spindle disturbances in liver cells, (b) may also modulate the drug-metabolizing liver enzyme function, and (c) downregulates the expression of its own microsomal specific binding site.en_US
dc.languageengen_US
dc.relation.ispartofArchives of Toxicologyen_US
dc.sourceArchives of Toxicology[ISSN 0340-5761],v. 75, p. 707-716 (Enero 2002)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3214 Toxicologíaen_US
dc.subject.otherAndrogen Cyproterone-Acetateen_US
dc.subject.otherDrug-Metabolizing-Enzymesen_US
dc.subject.otherSpindle Disturbancesen_US
dc.subject.otherAdaptive Responsesen_US
dc.subject.otherEthinyl Estradiolen_US
dc.subject.otherBinding-Sitesen_US
dc.subject.otherFemale Ratsen_US
dc.subject.otherV79 Cellsen_US
dc.subject.otherMicrosomesen_US
dc.subject.otherInductionen_US
dc.titleSteroid hormone progesterone induces cell proliferation and abnormal mitotic processes in rat liveren_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00204-001-0297-3en_US
dc.identifier.scopus0035716003-
dc.identifier.isi000174243300010-
dcterms.isPartOfArchives Of Toxicology-
dcterms.sourceArchives Of Toxicology[ISSN 0340-5761],v. 75 (11-12), p. 707-716-
dc.contributor.authorscopusid6603916807-
dc.contributor.authorscopusid6603459604-
dc.contributor.authorscopusid7003454772-
dc.contributor.authorscopusid7202801089-
dc.contributor.authorscopusid57192268038-
dc.contributor.authorscopusid7003696852-
dc.contributor.authorscopusid36892266500-
dc.contributor.authorscopusid6602257053-
dc.contributor.authorscopusid7003603506-
dc.description.lastpage716en_US
dc.description.firstpage707en_US
dc.relation.volume75en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000174243300010-
dc.contributor.daisngid697526-
dc.contributor.daisngid418822-
dc.contributor.daisngid301761-
dc.contributor.daisngid26233727-
dc.contributor.daisngid410842-
dc.contributor.daisngid31425686-
dc.contributor.daisngid2770121-
dc.contributor.daisngid6915984-
dc.contributor.daisngid2015573-
dc.contributor.daisngid2809080-
dc.contributor.daisngid8183416-
dc.contributor.daisngid31970075-
dc.contributor.daisngid1841045-
dc.contributor.daisngid1724161-
dc.identifier.investigatorRIDB-4495-2010-
dc.identifier.investigatorRIDL-5577-2015-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Boada, LD-
dc.contributor.wosstandardWOS:Zumbado, M-
dc.contributor.wosstandardWOS:del Rio, I-
dc.contributor.wosstandardWOS:Blanco, A-
dc.contributor.wosstandardWOS:Torres, S-
dc.contributor.wosstandardWOS:Monterde, JG-
dc.contributor.wosstandardWOS:Afonso, JL-
dc.contributor.wosstandardWOS:Cabrera, JJ-
dc.contributor.wosstandardWOS:Diaz-Chico, BN-
dc.date.coverdateEnero 2002en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0002-4184-6403-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameDomínguez Boada, Luis María-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNameCabrera Galván,Juan José-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
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