Peripheral blood reduction of memory (CD29⁺, CD45RO⁺, and "Bright" CD2⁺and LFA-1⁺) T lymphocytes in Papillon-Lefèvre syndrome

Abstract

A Papillon-Lef~vre patient with characteristic chronic periodontal disease and palmoplantar keratoderma was studied over a 4-year period. An abnormal T-cell phenotype was steadily observed in peripheral blood; both low numbers o f C D 2 9 + and C D 4 5 R O cells and a low density surface expression of CD2 and LFA-1 molecules were found. T-cell activation through CD3, CD2 and ConA, P W M and IL-2 receptors was normal; however, there was impairment in the activation via CD28. CD2, LFA-1 and CD45 molecules were normal in charge and molecular weight. There was no tissue sequestering o f T lymphocytes in periodontal lesions, but rather a relative T-cell reduction. It is suggested that an important decrease of the so-called memory/hyperreactive" .