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Title: Peripheral blood reduction of memory (CD29<sup>+</sup>, CD45RO<sup>+</sup>, and "Bright" CD2<sup>+</sup>and LFA-1<sup>+</sup>) T lymphocytes in Papillon-Lefèvre syndrome
Authors: Góngora, Rafael
Corell, Alfredo
Regueiro, Jose R.
Carasol, Miguel
Rodríguez-Gallego, Carlos 
Paz-Artal, Estela
Timón, Marcos
Allende, Luis
Arnaiz-Villena, Antonio
UNESCO Clasification: 32 Ciencias médicas
310903 Inmunología
Keywords: T Lymphocytes
Papillon-Lefevre Syndrome
Issue Date: 1994
Journal: Human Immunology 
Abstract: A Papillon-Lef~vre patient with characteristic chronic periodontal disease and palmoplantar keratoderma was studied over a 4-year period. An abnormal T-cell phenotype was steadily observed in peripheral blood; both low numbers o f C D 2 9 + and C D 4 5 R O cells and a low density surface expression of CD2 and LFA-1 molecules were found. T-cell activation through CD3, CD2 and ConA, P W M and IL-2 receptors was normal; however, there was impairment in the activation via CD28. CD2, LFA-1 and CD45 molecules were normal in charge and molecular weight. There was no tissue sequestering o f T lymphocytes in periodontal lesions, but rather a relative T-cell reduction. It is suggested that an important decrease of the so-called memory/hyperreactive" .
ISSN: 0198-8859
DOI: 10.1016/0198-8859(94)90035-3
Source: Human Immunology[ISSN 0198-8859],v. 41, p. 185-192
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