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Title: | Peripheral blood reduction of memory (CD29<sup>+</sup>, CD45RO<sup>+</sup>, and "Bright" CD2<sup>+</sup>and LFA-1<sup>+</sup>) T lymphocytes in Papillon-Lefèvre syndrome | Authors: | Góngora, Rafael Corell, Alfredo Regueiro, Jose R. Carasol, Miguel Rodríguez-Gallego, Carlos Paz-Artal, Estela Timón, Marcos Allende, Luis Arnaiz-Villena, Antonio |
UNESCO Clasification: | 32 Ciencias médicas 310903 Inmunología |
Keywords: | T Lymphocytes Papillon-Lefevre Syndrome |
Issue Date: | 1994 | Journal: | Human Immunology | Abstract: | A Papillon-Lef~vre patient with characteristic chronic periodontal disease and palmoplantar keratoderma was studied over a 4-year period. An abnormal T-cell phenotype was steadily observed in peripheral blood; both low numbers o f C D 2 9 + and C D 4 5 R O cells and a low density surface expression of CD2 and LFA-1 molecules were found. T-cell activation through CD3, CD2 and ConA, P W M and IL-2 receptors was normal; however, there was impairment in the activation via CD28. CD2, LFA-1 and CD45 molecules were normal in charge and molecular weight. There was no tissue sequestering o f T lymphocytes in periodontal lesions, but rather a relative T-cell reduction. It is suggested that an important decrease of the so-called memory/hyperreactive" . | URI: | http://hdl.handle.net/10553/48650 | ISSN: | 0198-8859 | DOI: | 10.1016/0198-8859(94)90035-3 | Source: | Human Immunology[ISSN 0198-8859],v. 41, p. 185-192 |
Appears in Collections: | Artículos |
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