Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48643
Title: Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain
Authors: García-Laorden, M. Isabel
Rúa-Figueroa, Iñigo
Pérez-Aciego, Paloma
Rodríguez-Pérez, J. Carlos 
Citores, M. Jesús
Álamo, Fayna
Erausquin, Celia
Rodríguez-Gallego, Carlos 
UNESCO Clasification: 32 Ciencias médicas
3205 Medicina interna
Keywords: SYSTEMIC LUPUS ERYTHEMATOSUS
AUTOANTIBODIES
MANNOSE BINDING LECTIN
COMPLEMENT
POLYMORPHISM
Issue Date: 2003
Journal: Journal of Rheumatology 
Abstract: Objective: To determine whether mannose binding lectin (MBL) polymorphisms are associated with clinical characteristics and with susceptibility to systemic lupus erythematosus (SLE) in women from the Canary Islands, Spain. Methods: MBL alleles and genotypes were determined by polymerase chain reaction in 89 female patients and 188 female controls. Results: No differences in the allelic or genotypic frequencies were observed between patients and controls. Anti-U1RNP autoantibodies were less frequent in association with mutated alleles (p = 0.037), and in association with MBL deficient genotypes, although this association was not statistically significant. The patients with low or nonproducer genotypes exhibited a decreased frequency of anti-Sm antibodies (p = 0.059). A nonsignificant trend toward lower prevalence of anti-Sm and anticardiolipin antibodies in association with both mutated alleles and low or nonproducer genotypes was also observed. The prevalence of more than one autoantibody was lower in association with mutated alleles (p = 0.022) and with low or nonproducer genotypes (p = 0.052). Homozygous or heterozygous patients with mutated alleles were significantly older at disease onset and at SLE diagnosis (p = 0.005, p = 0.014, respectively). An increase in the mean age at disease onset and at SLE diagnosis was observed with regard to the number of nonproducer alleles present (p = 0.021, p = 0.038, respectively). Conclusion: MBL deficiency is not a risk factor for SLE in women from the Canary Islands, but it is associated with lower prevalence of autoantibodies and with later age at disease onset and at SLE diagnosis.
URI: http://hdl.handle.net/10553/48643
ISSN: 0315-162X
Source: Journal of Rheumatology[ISSN 0315-162X],v. 30, p. 740-746 8abril 2003)
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