Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48642
Título: The dinucleotide repeat polymorphism in the 3′UTR of the CD154 qene has a functional role on protein expression and is associated with systemic lupus erythematosus
Autores/as: Citores, M. J.
Rua-Figueroa, I.
Rodriguez-Gallego, C. 
Durántez, A.
García-Laorden, M. I.
Rodríguez Lozano, C.
Rodríguez-Pérez, J. C. 
Vargas, J. A.
Pérez-Aciego, P.
Clasificación UNESCO: 3205 Medicina interna
Fecha de publicación: 2004
Editor/a: 0003-4967
Publicación seriada: Annals of the rheumatic diseases 
Resumen: Objective: To investigate the association of the (CA)n dinucleotide repeat in the 3′ untranslated region (3′UTR) of the CD154 gene with systemic lupus erythematosus (SLE), and its functional role in protein expression. Methods: The allelic and genotypic distributions of the polymorphism were compared in 80 patients with SLE and 80 controls. A complete clinical and analytical database was recorded in each patient in order to correlate the clinical manifestations in SLE with different alleles. To investigate the functional role of the polymorphism, the CD154 protein expression on activated lymphocytes from healthy homozygous controls was evaluated by flow cytometry. Results: The 24 CA allele was the most represented in controls (p = 0.029), whereas the alleles containing >24 CA repeats were found in patients (p = 0.0043). Furthermore, when only homozygous women were considered, most controls carried two 24 CA alleles (p = 0.041), whereas most patients carried two alleles containing >24 CA repeats (p = 0.032). Also, patients carrying at least one 24 CA allele had less neurological involvement (p = 0.034), and carriers of at least one allele with fewer than 24 CA repeats presented more livedo reticularis (p = 0.006) and anti-Sm (p = 0.01) and anti-RNP (p = 0.038) autoantibodies. CD154 maximum expression in activated lymphocytes from all controls was reached after 54 hours, but it was more prolonged in controls carrying two alleles with >24 CA repeats (p = 0.0068). Conclusion: The CD154 3′UTR microsatellite is associated with SLE, and the most represented alleles in patients were accompanied by a more prolonged protein expression in activated lymphocytes from controls.
URI: http://hdl.handle.net/10553/48642
ISSN: 0003-4967
DOI: 10.1136/ard.2003.006148
Fuente: Annals of the Rheumatic Diseases[ISSN 0003-4967],v. 63, p. 310-317
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