Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/48632
Campo DC | Valor | idioma |
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dc.contributor.author | Von Bernuth, Horst | en_US |
dc.contributor.author | Picard, Capucine | en_US |
dc.contributor.author | Jin, Zhongbo | en_US |
dc.contributor.author | Pankla, Rungnapa | en_US |
dc.contributor.author | Xiao, Hui | en_US |
dc.contributor.author | Ku, Cheng Lung | en_US |
dc.contributor.author | Chrabieh, Maya | en_US |
dc.contributor.author | Mustapha, Imen Ben | en_US |
dc.contributor.author | Ghandil, Pegah | en_US |
dc.contributor.author | Camcioglu, Yildiz | en_US |
dc.contributor.author | Vasconcelos, Júlia | en_US |
dc.contributor.author | Sirvent, Nicolas | en_US |
dc.contributor.author | Guedes, Margarida | en_US |
dc.contributor.author | Vitor, Artur Bonito | en_US |
dc.contributor.author | Herrero-Mata, María José | en_US |
dc.contributor.author | Aróstegui, Juan Ignacio | en_US |
dc.contributor.author | Rodrigo, Carlos | en_US |
dc.contributor.author | Alsina, Laia | en_US |
dc.contributor.author | Ruiz-Ortiz, Estibaliz | en_US |
dc.contributor.author | Juan, Manel | en_US |
dc.contributor.author | Fortuny, Claudia | en_US |
dc.contributor.author | Yagüe, Jordi | en_US |
dc.contributor.author | Antón, Jordi | en_US |
dc.contributor.author | Pascal, Mariona | en_US |
dc.contributor.author | Chang, Huey Hsuan | en_US |
dc.contributor.author | Janniere, Lucile | en_US |
dc.contributor.author | Rose, Yoann | en_US |
dc.contributor.author | Garty, Ben Zion | en_US |
dc.contributor.author | Chapel, Helen | en_US |
dc.contributor.author | Issekutz, Andrew | en_US |
dc.contributor.author | Maródi, László | en_US |
dc.contributor.author | Rodriguez-Gallego, Carlos | en_US |
dc.contributor.author | Banchereau, Jacques | en_US |
dc.contributor.author | Abel, Laurent | en_US |
dc.contributor.author | Li, Xiaoxia | en_US |
dc.contributor.author | Chaussabel, Damien | en_US |
dc.contributor.author | Puel, Anne | en_US |
dc.contributor.author | Casanova, Jean Laurent | en_US |
dc.date.accessioned | 2018-11-23T23:34:38Z | - |
dc.date.available | 2018-11-23T23:34:38Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.issn | 0036-8075 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/48632 | - |
dc.description.abstract | MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patients were otherwise healthy, with normal resistance to other microbes. Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Science | en_US |
dc.source | Science[ISSN 0036-8075],v. 321, p. 691-696 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 3205 Medicina interna | en_US |
dc.subject.other | MyD88 Deficiency | en_US |
dc.subject.other | Pyogenic bacterial infections | en_US |
dc.title | Pyogenic bacterial infections in humans with MyD88 deficiency | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1126/science.1158298 | en_US |
dc.identifier.scopus | 48749109290 | - |
dc.contributor.authorscopusid | 55983430500 | - |
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dc.contributor.authorscopusid | 7201863327 | - |
dc.description.lastpage | 696 | en_US |
dc.description.firstpage | 691 | en_US |
dc.relation.volume | 321 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.numberofpages | 6 | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Agosto 2008 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.scie | SCIE | - |
dc.description.erihplus | ERIH PLUS | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.orcid | 0000-0002-4344-8644 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Rodríguez Gallego, José Carlos | - |
Colección: | Artículos |
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