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Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48632
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dc.contributor.authorVon Bernuth, Horsten_US
dc.contributor.authorPicard, Capucineen_US
dc.contributor.authorJin, Zhongboen_US
dc.contributor.authorPankla, Rungnapaen_US
dc.contributor.authorXiao, Huien_US
dc.contributor.authorKu, Cheng Lungen_US
dc.contributor.authorChrabieh, Mayaen_US
dc.contributor.authorMustapha, Imen Benen_US
dc.contributor.authorGhandil, Pegahen_US
dc.contributor.authorCamcioglu, Yildizen_US
dc.contributor.authorVasconcelos, Júliaen_US
dc.contributor.authorSirvent, Nicolasen_US
dc.contributor.authorGuedes, Margaridaen_US
dc.contributor.authorVitor, Artur Bonitoen_US
dc.contributor.authorHerrero-Mata, María Joséen_US
dc.contributor.authorAróstegui, Juan Ignacioen_US
dc.contributor.authorRodrigo, Carlosen_US
dc.contributor.authorAlsina, Laiaen_US
dc.contributor.authorRuiz-Ortiz, Estibalizen_US
dc.contributor.authorJuan, Manelen_US
dc.contributor.authorFortuny, Claudiaen_US
dc.contributor.authorYagüe, Jordien_US
dc.contributor.authorAntón, Jordien_US
dc.contributor.authorPascal, Marionaen_US
dc.contributor.authorChang, Huey Hsuanen_US
dc.contributor.authorJanniere, Lucileen_US
dc.contributor.authorRose, Yoannen_US
dc.contributor.authorGarty, Ben Zionen_US
dc.contributor.authorChapel, Helenen_US
dc.contributor.authorIssekutz, Andrewen_US
dc.contributor.authorMaródi, Lászlóen_US
dc.contributor.authorRodriguez-Gallego, Carlosen_US
dc.contributor.authorBanchereau, Jacquesen_US
dc.contributor.authorAbel, Laurenten_US
dc.contributor.authorLi, Xiaoxiaen_US
dc.contributor.authorChaussabel, Damienen_US
dc.contributor.authorPuel, Anneen_US
dc.contributor.authorCasanova, Jean Laurenten_US
dc.date.accessioned2018-11-23T23:34:38Z-
dc.date.available2018-11-23T23:34:38Z-
dc.date.issued2008en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10553/48632-
dc.description.abstractMyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patients were otherwise healthy, with normal resistance to other microbes. Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections.en_US
dc.languageengen_US
dc.relation.ispartofScienceen_US
dc.sourceScience[ISSN 0036-8075],v. 321, p. 691-696en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherMyD88 Deficiencyen_US
dc.subject.otherPyogenic bacterial infectionsen_US
dc.titlePyogenic bacterial infections in humans with MyD88 deficiencyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1126/science.1158298en_US
dc.identifier.scopus48749109290-
dc.contributor.authorscopusid55983430500-
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dc.contributor.authorscopusid7006274073-
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dc.contributor.authorscopusid7201863327-
dc.description.lastpage696en_US
dc.description.firstpage691en_US
dc.relation.volume321en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages6en_US
dc.utils.revisionSíen_US
dc.date.coverdateAgosto 2008en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
dc.description.erihplusERIH PLUS
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-4344-8644-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
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