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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48433
DC FieldValueLanguage
dc.contributor.authorRivero, Argimiroen_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorEiroa, José Luisen_US
dc.contributor.authorLópez, Marianaen_US
dc.contributor.authorTriana, Jorgeen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherRivero, Argimiro-
dc.date.accessioned2018-11-23T21:45:36Z-
dc.date.available2018-11-23T21:45:36Z-
dc.date.issued2003en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10553/48433-
dc.description.abstractThis paper studies the cytotoxic effect induced by four known natural sesquiterpene lactones (tatridin A, tamirin, reynosin, ineupatorolide A) and one synthetic derivative (tatridin A diacetate) on the myeloid leukemia cell lines HL-60 and U937. Tatridin A diacetate and ineupatorolide A were found to be the most cytotoxic compounds with growth inhibition caused by induction of apoptosis as determined by flow cytometry and microscopy of nuclear changes. The results reported here support the conclusion that apoptosis was accompanied by both the activation of caspase-3 and the fragmentation of poly(ADP-ribose) polymerase-1 and was also associated with an early release of cytochrome c from the mitochondria.en_US
dc.languageengen_US
dc.relation.ispartofEuropean journal of pharmacologyen_US
dc.sourceEuropean Journal of Pharmacology[ISSN 0014-2999],v. 482, p. 77-84en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherPoly(Adp-Ribose) Polymeraseen_US
dc.subject.otherCytochrome-Cen_US
dc.subject.otherDeathen_US
dc.subject.otherHelenalinen_US
dc.subject.otherConstituentsen_US
dc.subject.otherChemotherapyen_US
dc.subject.otherInhibitorsen_US
dc.subject.otherCleavageen_US
dc.subject.otherReleaseen_US
dc.subject.otherAssayen_US
dc.titlePotent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejphar.2003.09.058en_US
dc.identifier.scopus0344737710-
dc.identifier.isi000187364500010-
dcterms.isPartOfEuropean Journal Of Pharmacology-
dcterms.sourceEuropean Journal Of Pharmacology[ISSN 0014-2999],v. 482 (1-3), p. 77-84-
dc.contributor.authorscopusid7005090783-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid6507583429-
dc.contributor.authorscopusid22985994700-
dc.contributor.authorscopusid6602859915-
dc.contributor.authorscopusid7101636723-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage84en_US
dc.description.firstpage77en_US
dc.relation.volume482en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000187364500010-
dc.contributor.daisngid7043918-
dc.contributor.daisngid128315-
dc.contributor.daisngid2831014-
dc.contributor.daisngid5158464-
dc.contributor.daisngid1400733-
dc.contributor.daisngid5695465-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages8en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Rivero, A-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Eiroa, JL-
dc.contributor.wosstandardWOS:Lopez, M-
dc.contributor.wosstandardWOS:Triana, J-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateDiciembre 2003en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,352-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IOCAG: Química Marina-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0003-0706-2434-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-4986-8332-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRivero Rosales, Argimiro-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEiroa Martínez,José Luis-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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