Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/48433
Título: | Potent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cells | Autores/as: | Rivero, Argimiro Quintana, J Eiroa, José Luis López, Mariana Triana, Jorge Bermejo, Jaime Estévez, Francisco |
Clasificación UNESCO: | 32 Ciencias médicas 3209 Farmacología |
Palabras clave: | Poly(Adp-Ribose) Polymerase Cytochrome-C Death Helenalin Constituents, et al. |
Fecha de publicación: | 2003 | Publicación seriada: | European journal of pharmacology | Resumen: | This paper studies the cytotoxic effect induced by four known natural sesquiterpene lactones (tatridin A, tamirin, reynosin, ineupatorolide A) and one synthetic derivative (tatridin A diacetate) on the myeloid leukemia cell lines HL-60 and U937. Tatridin A diacetate and ineupatorolide A were found to be the most cytotoxic compounds with growth inhibition caused by induction of apoptosis as determined by flow cytometry and microscopy of nuclear changes. The results reported here support the conclusion that apoptosis was accompanied by both the activation of caspase-3 and the fragmentation of poly(ADP-ribose) polymerase-1 and was also associated with an early release of cytochrome c from the mitochondria. | URI: | http://hdl.handle.net/10553/48433 | ISSN: | 0014-2999 | DOI: | 10.1016/j.ejphar.2003.09.058 | Fuente: | European Journal of Pharmacology[ISSN 0014-2999],v. 482, p. 77-84 |
Colección: | Artículos |
Citas SCOPUSTM
53
actualizado el 08-sep-2024
Citas de WEB OF SCIENCETM
Citations
53
actualizado el 08-sep-2024
Visitas
59
actualizado el 12-ago-2023
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.