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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48405
DC FieldValueLanguage
dc.contributor.authorTorres, Fernandoen_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorCabrera, Javieren_US
dc.contributor.authorLoro, Juan F.en_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherCabrera, Javier-
dc.contributor.otherTorres Andon, Fernando-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherLeon, Francisco-
dc.contributor.otherloro, juan-
dc.date.accessioned2018-11-23T21:28:01Z-
dc.date.available2018-11-23T21:28:01Z-
dc.date.issued2008en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10553/48405-
dc.description.abstractIn this study, we investigated the effect of three synthetic α-methylene-γ-butyrolactones (MBL) on viability of 10 human tumor cell lines and found that these lactones were highly cytotoxic against leukemia cells. Studies performed on HL-60 cells indicate that MBL induce G2-M arrest and apoptosis through a caspase-dependent mechanism. Apoptosis was associated to cytochrome c release, cleavage of procaspases-9 and -3, and hydrolysis of PARP. Intracellular reactive oxygen species (ROS) seem to play a key role since high levels of ROS were produced early (<15 min) and apoptosis was completely abrogated by the free radical scavenger N-acetyl-l-cysteine (NAC).en_US
dc.languageengen_US
dc.publisher0304-3835-
dc.relationDesarrollo de Nuevos, Mas Seguros y Mas Efectivos Compuestos Antileucemicosen_US
dc.relationNuevos Compuestos Antileucémicosen_US
dc.relation.ispartofCancer Lettersen_US
dc.sourceCancer Letters [ISSN 0304-3835], v. 269 (1), p. 139-147en_US
dc.subject3205 Medicina internaen_US
dc.subject.otherα-Methylene-γ-butyrolactonesen_US
dc.subject.otherApoptosisen_US
dc.subject.otherCaspasesen_US
dc.subject.otherDNA fragmentationen_US
dc.subject.otherPARP cleavageen_US
dc.subject.otherReactive oxygen speciesen_US
dc.titleInduction of G(2)-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.canlet.2008.04.028en_US
dc.identifier.scopus49349107092-
dc.identifier.isi000259847100016-
dcterms.isPartOfCancer Letters-
dcterms.sourceCancer Letters[ISSN 0304-3835],v. 269 (1), p. 139-147-
dc.contributor.authorscopusid55366045300-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid35598975600-
dc.contributor.authorscopusid6507389169-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid7101636723-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage147en_US
dc.identifier.issue1-
dc.description.firstpage139en_US
dc.relation.volume269en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000259847100016-
dc.contributor.daisngid34941095-
dc.contributor.daisngid2952604-
dc.contributor.daisngid128315-
dc.contributor.daisngid240124-
dc.contributor.daisngid3210878-
dc.contributor.daisngid29163246-
dc.contributor.daisngid136703-
dc.contributor.daisngid5695465-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDL-9179-2014-
dc.identifier.investigatorRIDD-5184-2009-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Torres, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Cabrera, J-
dc.contributor.wosstandardWOS:Loro, JF-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateSeptiembre 2008en_US
dc.identifier.ulpgcSíes
dc.description.jcr3,504
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-0517-8209-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameLoro Ferrer, Juan Francisco-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
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