Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48400
Campo DC Valoridioma
dc.contributor.authorPeña-Quintana, L.en_US
dc.contributor.authorTorres-Galván, M. J.en_US
dc.contributor.authorDéniz-Naranjo, M. C.en_US
dc.contributor.authorOrtigosa-Castillo, L.en_US
dc.contributor.authorRamos-Varela, J. C.en_US
dc.contributor.authorCalvo-Hernández, F.en_US
dc.contributor.authorFiuza-Pérez, M. D.en_US
dc.contributor.authorRodríguez-Gallego, J. C.en_US
dc.contributor.authorSánchez-García, Florentinoen_US
dc.date.accessioned2018-11-23T21:24:56Z-
dc.date.available2018-11-23T21:24:56Z-
dc.date.issued2003en_US
dc.identifier.issn0277-2116en_US
dc.identifier.urihttp://hdl.handle.net/10553/48400-
dc.description.abstractBackground: Celiac disease is a multifactorial disorder of the proximal small intestine associated with a permanent intolerance to gluten. The HLA-DQ(alpha1*0501, beta1*02) heterodimer is strongly associated with this disease. Materials and methods: The authors studied a sample of 354 unrelated Caucasoid individuals: 118 patients with celiac disease and 236 control subjects. All patients and controls subjects were born in Gran Canaria (Canary Islands) at least two generations ago. The authors typed the HLA-DQA1 and DQB1 genes by DNA methods. The positive and negative predictive values of the test were studied. Results: The mean age at diagnosis was 25.4 months, with a statistically significant proportion of females (64.4%, P < 0.002). For DQB1 gene, the susceptibility allele found was DQB1*02 (relative risk [RR] = 7.60, confidence interval [CI]: 5.35-10.78), whereas for the DQA1 gene, the susceptibility alleles found were DQA1*0501 (RR = 2.99, CI: 2.16-4.14) and DQA1*0201 (RR = 1.88, CI: 1.25-2.82). The presence of the DQ(alpha1*0501, beta1*02) heterodimer was strongly associated with the disease (92.4% in the patients group vs. 21.6% in control subjects). HLA-DQ8 heterodimer was absent in the authors' patients. DQB1*02 homozygous subjects presented a higher relative risk for celiac disease. There was no correlation of DQB1*02 dosage with age at onset below 12 years of age or with gender distribution. Sensitivity, specificity, and the positive and negative predictive values of the test were 92.4%, 78.4%, 68.1%, and 95.4%, respectively. Conclusions: The presence of the DQ2 (DQA1*0501/DQB1*02) heterodimer is strongly associated with celiac disease in the population studied by the authors. The value of this test derives from its ability to exclude disease when a negative result occurs.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.sourceJournal of Pediatric Gastroenterology and Nutrition[ISSN 0277-2116],v. 37(5), p. 604-608 (Noviembre 2003)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320503 Gastroenterologíaen_US
dc.subject320110 Pediatríaen_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherCeliac diseaseen_US
dc.subject.otherGene dosageen_US
dc.subject.otherDimerizationen_US
dc.subject.otherHLA-DQ(alpha1*0501, beta1*02)en_US
dc.subject.otherDQ2 (DQA1*0501/DQB1*02)en_US
dc.titleAssessment of the DQ heterodimer test in the diagnosis of celiac disease in the Canary Islands (Spain)en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1097/00005176-200311000-00019en_US
dc.identifier.scopus4644309133-
dc.contributor.authorscopusid6603266503-
dc.contributor.authorscopusid6602512211-
dc.contributor.authorscopusid6506081719-
dc.contributor.authorscopusid6507882168-
dc.contributor.authorscopusid6506825854-
dc.contributor.authorscopusid8250378600-
dc.contributor.authorscopusid6507362808-
dc.contributor.authorscopusid6506284420-
dc.contributor.authorscopusid7003798054-
dc.description.lastpage608en_US
dc.description.firstpage604en_US
dc.relation.volume37en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.date.coverdateNoviembre 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,402-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0001-6052-5894-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePeña Quintana, Luis-
crisitem.author.fullNameFiuza Pérez,Mª Dolores-
Colección:Artículos
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