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http://hdl.handle.net/10553/48327
Title: | Transient HBs antigenemia in patients on hemodialysis | Authors: | Santana Rodríguez, O. E. Morillas Jarillo, C. Esparza Martín, N. Toledo González, A. Checa Andrés, M. D. Martín Sánchez, A. M. |
UNESCO Clasification: | 32 Ciencias médicas 320102 Genética clínica |
Keywords: | Hepatitis-B Vaccine Surface Antigenemia |
Issue Date: | 1999 | Journal: | Revista clínica española (Ed. impresa) | Abstract: | Background. The presence of surface antigen of hepatitis B (HBsAg) virus in serum from recently vaccinated adults has been scarcely investigated. In this work, after the detection by chance of seven HBsAg-positive patients on hemodialysis who reported recent hepatitis B vaccination, a prospective study was undertaken to verify the presence and duration of post-vacunal antigenemia.Patients and methods. Nineteen non-selected patients on hemodialysis were followed for serologic markers of hepatitis B, after receiving a dose of the recombinant vaccine (Engerix B) according to their vaccination schedule. Enzyme-immunoassay techniques were used for the study of serologic markers, and the reactivity of HBsAg was confirmed by means of a neutralization assay with specific anti-HBs antibodies.Results. After the administration of one vaccine dose, 31.5% of patients were HBsAg positive at least once. Antigenemia was identified more frequently 2 to 4 days (83.3%) after inmunization. In all cases antigenemia was transient and had cleared after 11 days of vaccination. The follow-up of serologic markers revealed the absence of infection with virus B. Only 16.6% of patients with transient antigenemia responded to vaccination (titer of anti-HBs greater than or equal to 10 mIU/ml), while the corresponding percentage in the group of HBsAg-negative patients was 69.2% (p < 0.05). All patients were HCV and HIV negative.Conclusions. A high frequency of post-vacunal antigenemia is reported in patients on hemodialysis, in absence of virus B infection as well as the possible relationship between the presence of transient antigenemia and the non-responder status. | URI: | http://hdl.handle.net/10553/48327 | ISSN: | 0014-2565 | Source: | Revista Clinica Espanola[ISSN 0014-2565],v. 199, p. 198-201 |
Appears in Collections: | Artículos |
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