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Please use this identifier to cite or link to this item: https://accedacris.ulpgc.es/handle/10553/48245
DC FieldValueLanguage
dc.contributor.authorGuedes, Gemaen_US
dc.contributor.authorAmesty, Ángelen_US
dc.contributor.authorJiménez-Monzón, Robertoen_US
dc.contributor.authorMarrero-Alonso, Jorgeen_US
dc.contributor.authorDíaz, Marioen_US
dc.contributor.authorFernández Pérez, Leandroen_US
dc.contributor.authorEstévez-Braun, Anaen_US
dc.date.accessioned2018-11-23T20:06:37Z-
dc.date.available2018-11-23T20:06:37Z-
dc.date.issued2015en_US
dc.identifier.issn1860-7179en_US
dc.identifier.urihttps://accedacris.ulpgc.es/handle/10553/48245-
dc.description.abstractIn this study, a series of new 4,4-diaminotriphenylmethanes was efficiently synthesized from aromatic aldehydes and 2,5-dimethoxybenzenamine under microwave irradiation in the presence of Sc(OTf)(3) as a catalyst. Antiproliferative activity was assessed by using the MCF-7 estrogen receptor (ER)-positive breast cancer cell line, and antagonist/agonist transcriptional activities were determined. Docking studies and competition studies of triphenylmethanes and radiolabeled estradiol determined that these compounds do not bind the ER, indicating that triphenylmethane-induced changes in proliferative and transcriptional activities differ from conventional mechanisms of action triggered by other selective ER modulators.en_US
dc.languageengen_US
dc.relation"Evaluación Preclinica de Nuevas Estructuras Quimicas Diseñadas Para Inhibir la Ruta Oncogenica Jak-Stat O Como Moduladores Selectivos de Los Receptores Estrógenos"en_US
dc.relation.ispartofChemMedChemen_US
dc.sourceChemMedChem [ISSN 1860-7179], v. 10 (8), p. 1403-1412en_US
dc.subject32 Ciencias médicasen_US
dc.subject230207 Química clínicaen_US
dc.subject2390 Química farmacéuticaen_US
dc.subject.otherActivated Protein-Kinaseen_US
dc.subject.otherSolvent-Free Conditionsen_US
dc.subject.otherMolecular dockingen_US
dc.subject.otherSelective modulationen_US
dc.subject.otherEstrogen receptorsen_US
dc.subject.otherTriarylmethanesen_US
dc.titleSynthesis of 4,4′-Diaminotriphenylmethanes with Potential Selective Estrogen Receptor Modulator (SERM)-like Activityen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/cmdc.201500148en_US
dc.identifier.scopus84937971189-
dc.identifier.isi000358516200012-
dc.contributor.authorscopusid55371607800-
dc.contributor.authorscopusid14024036100-
dc.contributor.authorscopusid55329696800-
dc.contributor.authorscopusid12752675300-
dc.contributor.authorscopusid57195085150-
dc.contributor.authorscopusid7402043998-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid6701825073-
dc.description.lastpage1412en_US
dc.description.firstpage1403en_US
dc.relation.volume10en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid9546817-
dc.contributor.daisngid3211275-
dc.contributor.daisngid19892441-
dc.contributor.daisngid3824467-
dc.contributor.daisngid16872573-
dc.contributor.daisngid795544-
dc.contributor.daisngid425077-
dc.description.numberofpages10en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Guedes, G-
dc.contributor.wosstandardWOS:Amesty, A-
dc.contributor.wosstandardWOS:Jimenez-Monzon, R-
dc.contributor.wosstandardWOS:Marrero-Alonso, J-
dc.contributor.wosstandardWOS:Diaz, M-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Estevez-Braun, A-
dc.date.coverdateAgosto 2015en_US
dc.identifier.ulpgcSíen_US
dc.description.sjr1,148
dc.description.jcr2,98
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Francisco-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
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