Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48035
Title: Vincristine impairs platelet aggregation in dogs with lymphoma
Authors: Grau-Bassas, Enrique Rodriguez 
Kociba, Gary J.
Couto, C. Guillermo
Keywords: Thrombocytopenia
Issue Date: 2000
Publisher: 0891-6640
Journal: Journal of Veterinary Internal Medicine 
Abstract: Platelet aggregation before and after administration of 0.5 mg/m(2) of vincristine (VCR) was evaluated in 7 dogs with spontaneously occuring lymphoma. Aggregation on platelet-rich plasma separated from blood collected in 3.8% sodium citrate was performed using adenosine diphosphate (ADP), arachidonic acid (AA), and collagen (COL) as agonists. The slope for aggregation in response to ADP was significantly lower after administration of VCR (P = .032). Maximal aggregation after administration of VCR was significantly lower in response to ADP, COL, and AA (P = .03, P = .04, and P = .03, respectively).
URI: http://hdl.handle.net/10553/48035
ISSN: 0891-6640
DOI: 10.1111/j.1939-1676.2000.tb01503.x
Source: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine[ISSN 0891-6640],v. 14, p. 81-85
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