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http://hdl.handle.net/10553/47808
Título: | Collateral circulation in experimental coarctation of the aorta in minipigs: A possible association with hypertrophied vasa vasorum | Autores/as: | Aguirre-Sanceledonio, M. Fossum, T. W. Miller, M. W. Humphrey, J. D. Berridge, B. R. Herráez, P. |
Palabras clave: | Carotid-Artery Coronary-Arteries Neovascularization Atherosclerosis Angiogenesis, et al. |
Fecha de publicación: | 2003 | Editor/a: | 0021-9975 | Publicación seriada: | Journal of Comparative Pathology | Resumen: | Experimental coarctation of the thoracic aorta was produced in 13 adult Yucatan minipigs by placing a gradually expanding "C-shaped" occluder around the aorta. The aortic constriction was standardized by measuring the blood pressure above the coarctation, with a mean arterial pressure of 165-170 mmHg as the target. The pigs were humanely killed after 8 weeks of hypertension. No deaths were associated with constriction of the aorta, and neither rear limb weakness nor neurological dysfunction was noted. The lack of clinical signs in these animals suggested the development of an extensive collateral circulation. Collateral vessels, which were verified angiographically, included intercostal arteries, muscular intercostal arteries, and the internal thoracic artery. In two of the animals in which the thoracic aorta was completely occluded, revascularization also occurred via small arterial channels. Histologically, there was a marked increase in the number of vessels as well as significant hyperplasia and hypertrophy of smooth muscle of adventitial vasa vasorum. These findings support the hypothesis that collateralization of occluded thoracic aortas may be aided by hypertrophy of the vasa vasorum. To our knowledge, these vessels have not previously been shown convincingly by histopathological methods to revascularize occluded large arteries such as the aorta. (C) 2003 Elsevier Science Ltd. All rights reserved. | URI: | http://hdl.handle.net/10553/47808 | ISSN: | 0021-9975 | DOI: | 10.1053/jcpa.2002.0621 | Fuente: | Journal of Comparative Pathology[ISSN 0021-9975],v. 128, p. 165-171 |
Colección: | Artículos |
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