Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47808
Title: Collateral circulation in experimental coarctation of the aorta in minipigs: A possible association with hypertrophied vasa vasorum
Authors: Aguirre-Sanceledonio, M. 
Fossum, T. W.
Miller, M. W.
Humphrey, J. D.
Berridge, B. R.
Herráez, P. 
Keywords: Carotid-Artery
Coronary-Arteries
Neovascularization
Atherosclerosis
Angiogenesis, et al
Issue Date: 2003
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: Experimental coarctation of the thoracic aorta was produced in 13 adult Yucatan minipigs by placing a gradually expanding "C-shaped" occluder around the aorta. The aortic constriction was standardized by measuring the blood pressure above the coarctation, with a mean arterial pressure of 165-170 mmHg as the target. The pigs were humanely killed after 8 weeks of hypertension. No deaths were associated with constriction of the aorta, and neither rear limb weakness nor neurological dysfunction was noted. The lack of clinical signs in these animals suggested the development of an extensive collateral circulation. Collateral vessels, which were verified angiographically, included intercostal arteries, muscular intercostal arteries, and the internal thoracic artery. In two of the animals in which the thoracic aorta was completely occluded, revascularization also occurred via small arterial channels. Histologically, there was a marked increase in the number of vessels as well as significant hyperplasia and hypertrophy of smooth muscle of adventitial vasa vasorum. These findings support the hypothesis that collateralization of occluded thoracic aortas may be aided by hypertrophy of the vasa vasorum. To our knowledge, these vessels have not previously been shown convincingly by histopathological methods to revascularize occluded large arteries such as the aorta. (C) 2003 Elsevier Science Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/47808
ISSN: 0021-9975
DOI: 10.1053/jcpa.2002.0621
Source: Journal of Comparative Pathology[ISSN 0021-9975],v. 128, p. 165-171
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

7
checked on Sep 12, 2021

WEB OF SCIENCETM
Citations

6
checked on Sep 12, 2021

Page view(s)

15
checked on Sep 11, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.