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Title: Modification of loco-regional microenvironment in brain tumors by spinal cord stimulation. Implications for radio-chemotherapy
Authors: Clavo, B. 
Robaina, F.
Valcarcel, B.
Catala, L.
Perez, J. L.
Cabezon, A.
Jorge, I. J.
Fiuza Pérez, Mª Dolores 
Hernandez, M. A.
Jover, R.
Carreras, J. L.
UNESCO Clasification: 32 Ciencias médicas
321308 Neurocirugía
320101 Oncología
Keywords: Brain tumors
Spinal cord
Issue Date: 2012
Journal: Journal of Neuro-Oncology 
Abstract: The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral arteries (MCA) and (2) in common carotid arteries (CCA); (3) tumor blood-flow using single photon emission computed tomography (SPECT); (4) tumor-pO(2) (mmHg) using polarographic probes (eight tumor areas from five patients); and (5) tumor glucose metabolism using (18)F-fluoro-2-deoxyglucose ((18)FDG) positron emission tomography ((18)FDG-PET). Pre-SCS: tumor blood-flow was lower (P < 0.001) than peri-tumor areas and healthy contra-lateral areas. Tumor-pO(2) was lower (P < 0.042) than healthy tissue. Tumor glucose metabolism was higher than peri-tumor areas (P = 0.017) and healthy contra-lateral areas (P = 0.048). Post-SCS: there were increases in: MCA blood-flow (P ≤ 0.002), CCA blood-flow (P ≤ 0.013), tumor blood-flow (P = 0.033), tumor glucose metabolism (P = 0.027) and tumor-pO(2) (P = 0.022). The percentage of hypoxic values decreased (P = 0.007). SCS can modify tumor micro-environment. The potential usefulness of SCS in improving the effectiveness of radio-chemotherapy in HGG needs to be evaluated.
ISSN: 0167-594X
DOI: 10.1007/s11060-011-0660-z
Source: Journal of Neuro-Oncology [ISSN 0167-594X], v. 106, p. 177-184
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