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Title: Clinical subgroups in bilateral meniere disease
Authors: Frejo, Lidia
Soto-Varela, Andres
Santos-Perez, Sofía
Aran, Ismael
Batuecas-Caletrio, Angel
Perez-Guillen, Vanesa
Perez-Garrigues, Herminio
Fraile, Jesus
Martin-Sanz, Eduardo
Tapia, Maria C.
Trinidad, Gabriel
García-Arumi, Ana María
González-Aguado, Rocío
Espinosa-Sanchez, Juan M.
Marques, Pedro
Perez, Paz
Benitez, Jesus 
Lopez-Escamez, Jose A.
Amor-Dorado, Juan Carlos
Huarte, Raquel Manrique
Perez-Fernandez, Nicolas
Sanz, Ricardo
Dominguez, Manuel Oliva
Teggi, Roberto
UNESCO Clasification: 32 Ciencias médicas
320507 Neurología
Keywords: Meniere’s disease
Autoimmune disorders
Cluster analysis
Hearing loss
Inner ear, et al
Issue Date: 2016
Journal: Frontiers in Neurology 
Abstract: Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments. We have defined five clinical variants in BMD. Group 1 is the most frequently found, includes 46% of patients, and is defined by metachronic hearing loss without migraine and without AD. Group 2 is found in 17% of patients, and it is defined by synchronic hearing loss without migraine or AD. Group 3, with 13% of patients, is characterized by familial MD, while group 4, that includes 12% of patients, is associated by the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by AD. This approach can be helpful in selecting patients for genetic and clinical research. However, further studies will be required to improve the phenotyping in these clinical variants for a better understanding of the diverse etiological factors contributing to BMD.
ISSN: 1664-2295
DOI: 10.3389/fneur.2016.00182
Source: Frontiers in Neurology [1664-2295], v. 7 (182), (Octubre 2016)
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