Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47646
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dc.contributor.authorFrejo, L.en_US
dc.contributor.authorMartin-Sanz, E.en_US
dc.contributor.authorTeggi, R.en_US
dc.contributor.authorTrinidad, G.en_US
dc.contributor.authorSoto-Varela, A.en_US
dc.contributor.authorSantos-Perez, S.en_US
dc.contributor.authorManrique, R.en_US
dc.contributor.authorPerez, N.en_US
dc.contributor.authorAran, I.en_US
dc.contributor.authorAlmeida-Branco, M. S.en_US
dc.contributor.authorBatuecas-Caletrio, A.en_US
dc.contributor.authorFraile, J.en_US
dc.contributor.authorEspinosa-Sanchez, J. M.en_US
dc.contributor.authorPerez-Guillen, V.en_US
dc.contributor.authorPerez-Garrigues, H.en_US
dc.contributor.authorOliva-Dominguez, M.en_US
dc.contributor.authorAleman, O.en_US
dc.contributor.authorBenitez, J.en_US
dc.contributor.authorPerez, P.en_US
dc.contributor.authorLopez-Escamez, J. A.en_US
dc.contributor.authorAlemán, Oscaren_US
dc.contributor.authorAmor-Dorado, Juan Carlosen_US
dc.contributor.authorDominguez, Emilioen_US
dc.contributor.authorGarcía-Arumi, Ana Maríaen_US
dc.contributor.authorGonzález-Aguado, Rocíoen_US
dc.contributor.authorJimenez-Luna, Antonioen_US
dc.contributor.authorKnäpper, Jenniferen_US
dc.contributor.authorHuarte, Raquel Manriqueen_US
dc.contributor.authorPerez-Fernandez, Nicolasen_US
dc.contributor.authorMarques, Pedroen_US
dc.contributor.authorSanz, Ricardoen_US
dc.contributor.authorTapia, Maria Cruzen_US
dc.date.accessioned2018-11-23T15:14:06Z-
dc.date.available2018-11-23T15:14:06Z-
dc.date.issued2017en_US
dc.identifier.issn1749-4478en_US
dc.identifier.urihttp://hdl.handle.net/10553/47646-
dc.description.abstractObjectives To define clinical subgroups by cluster analysis in patients with unilateral Meniere disease (MD) and to compare them with the clinical subgroups found in bilateral MD. Design A cross-sectional study with a two-step cluster analysis. Settings A tertiary referral multicenter study. Participants Nine hundred and eighty-eight adult patients with unilateral MD. Main outcome measures: best predictors to define clinical subgroups with potential different aetiologies. Results We established five clusters in unilateral MD. Group 1 is the most frequently found, includes 53% of patients, and it is defined as the sporadic, classic MD without migraine and without autoimmune disorder (AD). Group 2 is found in 8% of patients, and it is defined by hearing loss, which antedates the vertigo episodes by months or years (delayed MD), without migraine or AD in most of cases. Group 3 involves 13% of patients, and it is considered familial MD, while group 4, which includes 15% of patients, is linked to the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by a comorbid AD. We found significant differences in the distribution of AD in clusters 3, 4 and 5 between patients with uni- and bilateral MD. Conclusions Cluster analysis defines clinical subgroups in MD, and it extends the phenotype beyond audiovestibular symptoms. This classification will help to improve the phenotyping in MD and facilitate the selection of patients for randomised clinical trials.en_US
dc.languageengen_US
dc.relation.ispartofClinical Otolaryngologyen_US
dc.sourceClinical Otolaryngology[ISSN 1749-4478],v. 42, p. 1172-1180 (Febrero 2017)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3201 Ciencias clínicasen_US
dc.subject.otherPhenotypeen_US
dc.subject.otherMeniere diseaseen_US
dc.subject.otherCross-sectional studyen_US
dc.subject.otherCluster analysisen_US
dc.titleExtended phenotype and clinical subgroups in unilateral Meniere disease: A cross-sectional study with cluster analysisen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/coa.12844en_US
dc.identifier.scopus2-s2.0-85013820333-
dc.contributor.authorscopusid56786412200-
dc.contributor.authorscopusid6507212340-
dc.contributor.authorscopusid57192338920-
dc.contributor.authorscopusid57191956091-
dc.contributor.authorscopusid6602851776-
dc.contributor.authorscopusid6602791690-
dc.contributor.authorscopusid23492852400-
dc.contributor.authorscopusid7101856812-
dc.contributor.authorscopusid23472050500-
dc.contributor.authorscopusid57024135900-
dc.contributor.authorscopusid8327341500-
dc.contributor.authorscopusid56995750800-
dc.contributor.authorscopusid6507717457-
dc.contributor.authorscopusid12763590300-
dc.contributor.authorscopusid6603815284-
dc.contributor.authorscopusid56161923300-
dc.contributor.authorscopusid7801576607-
dc.contributor.authorscopusid56878370600-
dc.contributor.authorscopusid7201902655-
dc.contributor.authorscopusid7003654696-
dc.contributor.authorscopusid57197809451-
dc.contributor.authorscopusid6602775710-
dc.contributor.authorscopusid57197812416-
dc.contributor.authorscopusid6507609905-
dc.contributor.authorscopusid25636936900-
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dc.contributor.authorscopusid57197814985-
dc.contributor.authorscopusid56658732200-
dc.contributor.authorscopusid6602382611-
dc.contributor.authorscopusid35622479300-
dc.contributor.authorscopusid35751459200-
dc.contributor.authorscopusid57200741047-
dc.description.lastpage1180en_US
dc.description.firstpage1172en_US
dc.relation.volume42en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.date.coverdateFebrero 2017en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,846-
dc.description.jcr2,696-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.fullNameBenítez Del Rosario, Jesús-
Colección:Artículos
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