Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47549
Title: Immunophenotypic characterization of hepatic inflammatory cell infiltrates in common dolphins (Delphinus delphis)
Authors: Jáber Mohamad, José Raduán 
Pérez Arevalo,Jose 
Arbelo Hernández, Manuel Antonio 
Herráez Thomas, Pedro Manuel 
Espinosa De Los Monteros Y Zayas, Antonio 
Rodńguez, F.
Fernández, T. 
Fernández Rodríguez, Antonio Jesús 
UNESCO Clasification: 240111 Patología animal
310907 Patología
240119 Zoología marina
240118 Mamíferos
Keywords: Cholangitis
Delphinus delphis
Dolphin
Hepatitis
Parasitic infection
Issue Date: 2003
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: Of 14 common dolphins, 12 showed non-specific reactive hepatitis and three chronic parasitic cholangitis with lymphoid proliferation. Non-specific reactive hepatitis was shown immunohistochemically to beassociated with small clusters of CD3+ cells in portal areas and hepatic sinusoids. Polyclonal antibody against S100 protein reacted with a variable number of lymphocytes from portal areas and hepaticsinusoids, as well as with Kupffer cells and epithelial cells of the bile ducts. The majority of plasma cells observed in portal areas and hepatic sinusoids were IgG+. In lymphonodular lesions of chronic parasiticcholangitis, the distribution of immunoreactive cells was similar to that found in the cortex of lymphnodes. The presence of stellate cells similar to follicular dendritic and interdigitating cells expressing S-100 protein and MHC class II antigen in lymphonodular lesions suggested that these were highly organized structures developed to enhance antigen presentation to B and T cells.
URI: http://hdl.handle.net/10553/47549
ISSN: 0021-9975
DOI: 10.1016/S0021-9975(03)00008-2
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 129 (2-3), p. 226-230
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