Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47515
Title: Morbillivirus infection in cetaceans stranded along the Italian coastline: Pathological, immunohistochemical and biomolecular findings
Authors: Di Guardo, Giovanni
Di Francesco, Cristina Esmeralda
Eleni, Claudia
Cocumelli, Cristiano
Scholl, Francesco
Casalone, Cristina
Peletto, Simone
Mignone, Walter
Tittarelli, Cristiana
Di Nocera, Fabio
Leonardi, Leonardo
Fernández Rodríguez, Antonio Jesús 
Marcer, Federica
Mazzariol, Sandro
UNESCO Clasification: 240111 Patología animal
310907 Patología
Keywords: Dolphin-Morbillivirus
Toxoplasma-Gondii
Stenella-Coeruleoalba
Aquatic Mammals
Encephalitis, et al
Issue Date: 2013
Publisher: 0034-5288
Journal: Research in Veterinary Science 
Abstract: Morbilliviruses are recognized as biological agents highly impacting the health and conservation status of free-ranging cetaceans worldwide, as clearly exemplified by the two Dolphin Morbillivirus (DMV) epidemics of 1990-1992 and 2006-2008 among Mediterranean striped dolphins (Stenella coeruleoalba). After these two epidemics, morbilliviral infection (MI) cases with peculiar neurobiological features were reported in striped dolphins stranded along the Spanish coastline. Affected cetaceans showed a subacute-to-chronic, non-suppurative encephalitis, with brain lesions strongly resembling those found in human "subacute sclerosing panencephalitis" and "old dog encephalitis". Brain was the only tissue in which morbilliviral antigen and/or genome could be detected.Beside a case of morbilliviral encephalitis in a striped dolphin's calf stranded in 2009, we observed 5 additional MI cases in 2 striped dolphins, 1 bottlenose dolphin (Tursiops truncatus) and 2 fin whales (Balaenoptera physalus), all stranded in 2011 along the Italian coastline. Noteworthy, 3 of these animals (2 striped dolphins and I bottlenose dolphin) showed immunohistochemical (IHC) and/or biomolecular (PCR) evidence of morbilliviral antigen and/or genome exclusively in their brain, with 1 striped dolphin and I bottlenose dolphin also exhibiting a non-suppurative encephalitis. Furthermore, simultaneous IHC and PCR evidence of a Toxoplasma gondii coinfection was obtained in I fin whale.The above results are consistent with those reported in striped dolphins after the two MI epidemics of 1990-92 and 2006-2008, with evidence of morbilliviral antigen and/or genome being found exclusively in the brain tissue from affected animals.
URI: http://hdl.handle.net/10553/47515
ISSN: 0034-5288
DOI: 10.1016/j.rvsc.2012.07.030
Source: Research in Veterinary Science [ISSN 0034-5288], v. 94 (1), p. 132-137
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

38
checked on Jun 26, 2022

WEB OF SCIENCETM
Citations

38
checked on Jun 26, 2022

Page view(s)

19
checked on May 21, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.