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Title: Cetacean morbillivirus: Current knowledge and future directions
Authors: Van Bressem, Marie Françoise
Duignan, Pádraig J.
Banyard, Ashley
Barbieri, Michelle
Colegrove, Kathleen M.
de Guise, Sylvain
di Guardo, Giovanni
Dobson, Andrew
Domingo, Mariano
Fauquier, Deborah
Fernandez, Antonio 
Goldstein, Tracey
Grenfell, Bryan
Groch, Kátia R.
Gulland, Frances
Jensen, Brenda A.
Jepson, Paul D.
Hall, Ailsa
Kuiken, Thijs
Mazzariol, Sandro
Morris, Sinead E.
Nielsen, Ole
Raga, Juan A.
Rowles, Teresa K.
Saliki, Jeremy
Sierra, Eva 
Stephens, Nahiid
Stone, Brett
Tomo, Ikuko
Wang, Jianning
Waltzek, Thomas
Wellehan, James F.X.
Keywords: Bottle-Nosed Dolphins
Porpoises Phocoena-Phocoena
Striped Dolphins
Epithelial Receptor
Postmortem Findings
Issue Date: 2014
Journal: Viruses 
Abstract: We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents a distinct species within the Morbillivirus genus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemically infected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported.
ISSN: 1999-4915
DOI: 10.3390/v6125145
Source: Viruses-Basel[ISSN 1999-4915],v. 6 (12), p. 5145-5181
Appears in Collections:Reseña
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