Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47509
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dc.contributor.authorVan Bressem, Marie Françoiseen_US
dc.contributor.authorDuignan, Pádraig J.en_US
dc.contributor.authorBanyard, Ashley C.en_US
dc.contributor.authorBarbieri, Michelle M.en_US
dc.contributor.authorColegrove, Kathleen M.en_US
dc.contributor.authorde Guise, Sylvainen_US
dc.contributor.authorDi Guardo, Giovannien_US
dc.contributor.authorDobson, Andrew D. M.en_US
dc.contributor.authorDomingo Álvarez, Marianoen_US
dc.contributor.authorFauquier, Deborah A.en_US
dc.contributor.authorFernández Rodríguez, Antonio Jesúsen_US
dc.contributor.authorGoldstein, Tracey A.en_US
dc.contributor.authorGrenfell, Bryan T.en_US
dc.contributor.authorGroch, Kátia Reginaen_US
dc.contributor.authorGulland, Frances M. D.en_US
dc.contributor.authorJensen, Brenda A.en_US
dc.contributor.authorJepson, Paul D.en_US
dc.contributor.authorHall, Ailsa J.en_US
dc.contributor.authorKuiken, Thijsen_US
dc.contributor.authorMazzariol, Sandroen_US
dc.contributor.authorMorris, Sinead E.en_US
dc.contributor.authorNielsen, Oleen_US
dc.contributor.authorRaga Esteve, Juan Antonioen_US
dc.contributor.authorRowles, Teresa K.en_US
dc.contributor.authorSaliki, Jeremiah T.en_US
dc.contributor.authorSierra Pulpillo, Eva Maríaen_US
dc.contributor.authorStephens, Nahiiden_US
dc.contributor.authorStone, Brett M.en_US
dc.contributor.authorTomo, Ikukoen_US
dc.contributor.authorWang, Jianningen_US
dc.contributor.authorWaltzek, Thomas B.en_US
dc.contributor.authorWellehan, James Fx X.en_US
dc.contributor.otherFernandez, Antonio-
dc.contributor.otherBanyard, Ashley-
dc.contributor.otherSierra, Eva-
dc.contributor.otherAPHA, Staff publications-
dc.contributor.otherRaga, Juan Antonio-
dc.contributor.otherMazzariol, Sandro-
dc.contributor.otherHall, Ailsa-
dc.date.accessioned2018-11-23T14:07:31Z-
dc.date.available2018-11-23T14:07:31Z-
dc.date.issued2014en_US
dc.identifier.issn1999-4915en_US
dc.identifier.urihttp://hdl.handle.net/10553/47509-
dc.description.abstractWe review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents a distinct species within the Morbillivirus genus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemically infected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported.en_US
dc.languageengen_US
dc.relation.ispartofVirusesen_US
dc.sourceViruses [ISSN 1999-4915], v. 6 (12), p. 5145-5181en_US
dc.subject242091 Virología animalen_US
dc.subject310911 Virologíaen_US
dc.subject240118 Mamíferosen_US
dc.subject.otherBottle-Nosed Dolphinsen_US
dc.subject.otherCanine-Distemper-Virusen_US
dc.subject.otherPorpoises Phocoena-Phocoenaen_US
dc.subject.otherPolymerase-Chain-Reactionen_US
dc.subject.otherMeasles-Virusen_US
dc.subject.otherStriped Dolphinsen_US
dc.subject.otherStenella-Coeruleoalbaen_US
dc.subject.otherTursiops-Truncatusen_US
dc.subject.otherEpithelial Receptoren_US
dc.subject.otherPostmortem Findingsen_US
dc.subject.otherCetacean morbillivirusen_US
dc.subject.otherEpidemicsen_US
dc.subject.otherMass strandingen_US
dc.subject.otherSLAMen_US
dc.subject.otherSignaling Lymphocyte Activation Moleculeen_US
dc.subject.otherPhylogenyen_US
dc.subject.otherPathogenesisen_US
dc.subject.otherDiagnosisen_US
dc.subject.otherEndemic infectionsen_US
dc.titleCetacean morbillivirus: Current knowledge and future directionsen_US
dc.typeinfo:eu-repo/semantics/reviewen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/v6125145en_US
dc.identifier.scopus84919820072-
dc.identifier.isi000346834500017-
dcterms.isPartOfViruses-Basel
dcterms.sourceViruses-Basel[ISSN 1999-4915],v. 6 (12), p. 5145-5181
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dc.description.lastpage5181en_US
dc.description.firstpage5145en_US
dc.relation.volume6en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Reseñaen_US
dc.identifier.wosWOS:000346834500017-
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dc.identifier.investigatorRIDG-3448-2015-
dc.identifier.investigatorRIDC-7998-2011-
dc.identifier.investigatorRIDH-9352-2015-
dc.identifier.investigatorRIDE-6082-2010-
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dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Van Bressem, MF-
dc.contributor.wosstandardWOS:Duignan, PJ-
dc.contributor.wosstandardWOS:Banyard, A-
dc.contributor.wosstandardWOS:Barbieri, M-
dc.contributor.wosstandardWOS:Colegrove, KM-
dc.contributor.wosstandardWOS:De Guise, S-
dc.contributor.wosstandardWOS:Di Guardo, G-
dc.contributor.wosstandardWOS:Dobson, A-
dc.contributor.wosstandardWOS:Domingo, M-
dc.contributor.wosstandardWOS:Fauquier, D-
dc.contributor.wosstandardWOS:Fernandez, A-
dc.contributor.wosstandardWOS:Goldstein, T-
dc.contributor.wosstandardWOS:Grenfell, B-
dc.contributor.wosstandardWOS:Groch, KR-
dc.contributor.wosstandardWOS:Gulland, F-
dc.contributor.wosstandardWOS:Jensen, BA-
dc.contributor.wosstandardWOS:Jepson, PD-
dc.contributor.wosstandardWOS:Hall, A-
dc.contributor.wosstandardWOS:Kuiken, T-
dc.contributor.wosstandardWOS:Mazzariol, S-
dc.contributor.wosstandardWOS:Morris, SE-
dc.contributor.wosstandardWOS:Nielsen, O-
dc.contributor.wosstandardWOS:Raga, JA-
dc.contributor.wosstandardWOS:Rowles, TK-
dc.contributor.wosstandardWOS:Saliki, J-
dc.contributor.wosstandardWOS:Sierra, E-
dc.contributor.wosstandardWOS:Stephens, N-
dc.contributor.wosstandardWOS:Stone, B-
dc.contributor.wosstandardWOS:Tomo, I-
dc.contributor.wosstandardWOS:Wang, J-
dc.contributor.wosstandardWOS:Waltzek, T-
dc.contributor.wosstandardWOS:Wellehan, JFX-
dc.date.coverdateDiciembre 2014en_US
dc.identifier.ulpgcen_US
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dc.contributor.buulpgcBU-VETen_US
dc.contributor.buulpgcBU-VETen_US
dc.contributor.buulpgcBU-VETen_US
dc.contributor.buulpgcBU-VETen_US
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptHistología y Patología Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.orcid0000-0003-3749-8845-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
crisitem.author.fullNameSierra Pulpillo, Eva María-
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