Please use this identifier to cite or link to this item:
Title: Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs
Authors: Vilar Guereño, José Manuel 
Morales Doreste, Manuel Francisco 
Santana Del Pino, Ángelo 
Spinella, Giuseppe
Rubio Zaragoza, Mónica
Cuervo Serrato, Belén
Cugat Bertomeu, Ramón
Carrillo Poveda, José María
UNESCO Clasification: 240111 Patología animal
310907 Patología
Keywords: Cranial Cruciate Ligament
Gait Analysis
Tissue, et al
Issue Date: 2013
Journal: BMC Veterinary Research 
Abstract: Background: Adipose-derived mesenchymal stem cell (ADMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with AD-MSC.The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA. Results: Eight lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved after treatment of the OA groups, reaching 53.02% and 14.84% of body weight, respectively, at day 180, compared with only 43.56% and 12.16% at day 0. Conclusion: This study objectively demonstrated that intraarticular ADMSC therapy resulted in reduced lameness due to OA.
ISSN: 1746-6148
DOI: 10.1186/1746-6148-9-131
Source: BMC Veterinary Research [ISSN 1746-6148], v. 9, 131
Appears in Collections:Artículos
Show full item record

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.