Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47247
Título: Invasion and intracellular survival of Hafnia alvei strains in human epithelial cells
Autores/as: Padilla, D. 
Acosta, F. 
Bravo, Jimena 
Grasso, V.
Real Valcárcel, Fernando 
Vivas, J.
Palabras clave: Enteropathogenic Escherichia-Coli
In-Vitro
Acute Gastroenteritis
Bacterial Invasion
Genus Hafnia, et al.
Fecha de publicación: 2008
Editor/a: 1364-5072
Publicación seriada: Journal of Applied Microbiology 
Resumen: Aims: The aim of this study was to investigate the invasion and intracellular survival of different Hafnia alvei strains in HeLa cells.Methods and Results: We performed different experiments on the bacterial invasion of different strains of H. alvei into the HeLa cell line using gentamicin protection assays and immunofluorescence. We also report the time course of cell internalization and the effects of inhibitors on the invasion of H. alvei. Levels of invasion varied depending on the conditions (strain, time and inoculum size) used.Conclusions: This study revealed that H. alvei strains were able to enter and persist in a human epithelial cell line.Significance and Impact of the Study: Our in vitro findings highlight the possibility that some H. alvei strains may exploit nonprofessional phagocytes or nonphagocytic cells to spread in vivo, which may be important for the persistence and establishment of an asymptomatic carrier state.
URI: http://hdl.handle.net/10553/47247
ISSN: 1364-5072
DOI: 10.1111/j.1365-2672.2008.03884.x
Fuente: Journal of Applied Microbiology[ISSN 1364-5072],v. 105, p. 1614-1622
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