Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47222
DC FieldValueLanguage
dc.contributor.authorEl Aamri, F.en_US
dc.contributor.authorReal Valcárcel, Fernandoen_US
dc.contributor.authorAcosta, F.en_US
dc.contributor.authorBravo García, Jimenaen_US
dc.contributor.authorRomán, L.en_US
dc.contributor.authorDéniz, S.en_US
dc.contributor.authorPadilla, D.en_US
dc.date.accessioned2018-11-23T11:48:43Z-
dc.date.available2018-11-23T11:48:43Z-
dc.date.issued2015en_US
dc.identifier.issn1050-4648en_US
dc.identifier.urihttp://hdl.handle.net/10553/47222-
dc.description.abstractStreptococcus iniae is a Gram-positive bacteria that causes invasive infections with severe septicemia and meningitis, producing high economic losses in marine and continental aquaculture. Head kidney leukocytes of European sea bass (Dicentrarchus labrax) were used to measure the differential innate immune response upon infection with S. iniae. The complete inhibition in the production of intracellular superoxide radicals and total peroxidase content was observed in infected cells. This study also elucidates changes in the relative expression of some immune-related genes. Interleukin 1 beta, tumor necrosis factor-a and interleukin-6 reached a peak of expression at 4-8 h post-infection, subsequently decreasing significantly up to 48 h post-infection. However, interleukin-10 and Mx protein increased over time, reaching the pick of expression at 48 h post-infection, whereas caspase-3 showed down regulation until 48 h post-infection. The in vivo study of immune related genes show the same kinetics of mRNAs expression as in vitro experience. The proinflammatory cytokines mRNA transcription levels peaked at an earlier time in vivo than in vitro system. Our findings indicate that there is a direct relationship between the dissemination of bacteria and the resulting infection-associated inhibition of respiratory burst, apoptosis, and the pro- and anti-inflammatory gene expression profiles. (C) 2015 Published by Elsevier Ltd.en_US
dc.languageengen_US
dc.publisher1050-4648
dc.relation.ispartofFish and Shellfish Immunologyen_US
dc.sourceFish and Shellfish Immunology[ISSN 1050-4648],v. 46, p. 436-441en_US
dc.subject310905 Microbiologíaen_US
dc.subject.otherSalmo-Salar L.en_US
dc.subject.otherAtlantic Salmonen_US
dc.subject.otherRainbow-Trouten_US
dc.subject.otherMeasure Degranulationen_US
dc.subject.otherExpression Analysisen_US
dc.subject.otherRespiratory Bursten_US
dc.subject.otherMolecular-Cloningen_US
dc.subject.otherAdaptive Immunityen_US
dc.subject.otherDirect Assayen_US
dc.subject.otherFishen_US
dc.titleDifferential innate immune response of European seabass (Dicentrarchus labrax) against Streptococcus iniaeen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fsi.2015.05.054en_US
dc.identifier.scopus84938066597-
dc.identifier.isi000363071200031-
dc.contributor.authorscopusid55351966600-
dc.contributor.authorscopusid7005397318-
dc.contributor.authorscopusid56269311600-
dc.contributor.authorscopusid23059544100-
dc.contributor.authorscopusid50661926900-
dc.contributor.authorscopusid7003859353-
dc.contributor.authorscopusid7005088705-
dc.description.lastpage441en_US
dc.description.firstpage436en_US
dc.relation.volume46en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid3017971-
dc.contributor.daisngid32158446-
dc.contributor.daisngid878226-
dc.contributor.daisngid1844262-
dc.contributor.daisngid16153744-
dc.contributor.daisngid28148410-
dc.contributor.daisngid1039753-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:El Aamri, F-
dc.contributor.wosstandardWOS:Real, F-
dc.contributor.wosstandardWOS:Acosta, F-
dc.contributor.wosstandardWOS:Bravo, J-
dc.contributor.wosstandardWOS:Roman, L-
dc.contributor.wosstandardWOS:Deniz, S-
dc.contributor.wosstandardWOS:Padilla, D-
dc.date.coverdateOctubre 2015en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,268
dc.description.jcr3,025
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONE HEALTH 2.-Sanidad Animal de la Acuicultura y Especies Silvestres, Enfermedades Infecciosas y Seguridad Alimentaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR ECOAQUA: Grupo de Investigación en Acuicultura-
crisitem.author.deptIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONE HEALTH 2.-Sanidad Animal de la Acuicultura y Especies Silvestres, Enfermedades Infecciosas y Seguridad Alimentaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONE HEALTH 2.-Sanidad Animal de la Acuicultura y Especies Silvestres, Enfermedades Infecciosas y Seguridad Alimentaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0001-6526-0354-
crisitem.author.orcid0000-0002-1098-7529-
crisitem.author.orcid0000-0002-3237-1020-
crisitem.author.orcid0000-0003-0201-8338-
crisitem.author.orcid0000-0002-6678-5029-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameReal Valcárcel, Fernando-
crisitem.author.fullNameAcosta Arbelo, Félix Antonio-
crisitem.author.fullNameBravo García, Jimena-
crisitem.author.fullNameDéniz Suárez, María Soraya-
crisitem.author.fullNamePadilla Castillo, Daniel Fermín-
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