Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47220
Title: Acinetobacter baumannii and A. pittii clinical isolates lack adherence and cytotoxicity to lung epithelial cells in vitro
Authors: Lázaro-Díez, María
Navascués-Lejarza, Teresa
Remuzgo-Martínez, Sara
Navas, Jesús
Icardo, José Manuel
Acosta, Felix 
Martínez-Martínez, Luis
Ramos-Vivas, José
Keywords: Complex
Issue Date: 2016
Publisher: 1286-4579
Journal: Microbes and Infection 
Abstract: The molecular and genetic basis of Acinetobacter baumannii and Acinetobacter pittii virulence remains poorly understood, and there is still lack of knowledge in host cell response to these bacteria. In this study, we have used eleven clinical Acinetobacter strains (A. baumannii n = 5; A. pittii n = 6) to unravel bacterial adherence, invasion and cytotoxicity to human lung epithelial cells. Our results showed that adherence to epithelial cells by Acinetobacter strains is scarce and cellular invasion was not truly detected. In addition, all Acinetobacter strains failed to induce any cytotoxic effect on A549 cells. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
URI: http://hdl.handle.net/10553/47220
ISSN: 1286-4579
DOI: 10.1016/j.micinf.2016.05.002
Source: Microbes and Infection[ISSN 1286-4579],v. 18, p. 559-564
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