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Title: Simultaneous optimization of surfactant concentration and organic modifier in micellar liquid chromatography. Application to the separation of phenolic compounds
Authors: Mahugo Santana,Cristina Isabel 
Sosa Ferrera, Z. 
Santana Rodriguez, J. J. 
UNESCO Clasification: 2301 química analítica
Keywords: Liquid chromatography
Issue Date: 2000
Publisher: 0003-2719
Journal: Analytical letters 
Abstract: The separation selectivity of eighteen phenolic derivatives in micellar high-performance liquid chromatography was studied as a function of parameters on which it depends: surfactant and organic modifier concentration. The surfactant used in this study was cetyltrimethylammonium bromide, and as organic modifier methanol. An iterative regression optimization strategy for these two parameters has been used. The equation that best explains the experimental results is 1/k' = A +Bμ + Cφ + DμΦ. We propose the use of this model in conjunction with the appropriate factorial design to predict the solute retention behaviour in micellar liquid chromatography with hibrid eluents.
ISSN: 0003-2719
DOI: 10.1080/00032710008543154
Source: Analytical Letters [ISSN 0003-2719], v. 33, p. 1691-1709
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