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Title: Preconcentration of pharmaceuticals residues in sediment samples using microwave assisted micellar extraction coupled with solid phase extraction and their determination by HPLC-UV
Authors: Cueva-Mestanza, R.
Sosa-Ferrera, Z. 
Torres-Padrón, M. E. 
Santana-Rodríguez, J. J. 
UNESCO Clasification: 2301 química analítica
2391 Química ambiental
Keywords: Pharmaceuticals residues
Microwave assisted micellar extraction
Solid phase extraction
Issue Date: 2008
Publisher: 1570-0232
Project: Acoplamiento de la Microextracción en Fase Sólida y la Cromatografía Líquida de Alta Resolución Con la Utilización de Medios Micelares Como Extractantes: Desarrollo de Nuevos Métodos Analíticos 
Journal: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 
Abstract: An analytical method combining microwave assisted micellar extraction (MAME) and solid phase extraction (SPE) has been developed to extract and preconcentrate a selected group of eight pharmaceutical compounds in sediment samples prior to their determination using liquid chromatography with an UV–DAD detector. A non-ionic surfactant, Polyoxyethylene 10 lauryl ether (POLE) was used for the MAME extraction and the different parameters for the optimization process were studied. Then, SPE was used to clean-up and preconcentrate the target analytes in the extract, prior to their determination using HPLC–UV. The method was applied to the determination of the selected pharmaceuticals compounds in several kinds of sediment samples with different characteristics. Relative recoveries for spiked sediment samples were over 70% and relative standard deviations (RSDs) were under 11% for all recoveries tested. Detection limits between 4 and 167 ng g−1 were obtained. The method was validated using Soxhlet extraction procedure.
ISSN: 1570-0232
DOI: 10.1016/j.jchromb.2008.01.026
Source: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences [ISSN 1570-0232], v. 863, p. 150-157
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