Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47122
Title: A dispersive liquid-liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra-high-performace liquid chromatography with DAD detection
Authors: Montesdeoca-Esponda, Sarah 
Mahugo Santana,Cristina Isabel 
Sosa-Ferrera, Zoraida 
Santana-Rodríguez, José Juan 
UNESCO Clasification: 2301 química analítica
330810 Tecnología de aguas residuales
Keywords: Pharmaceutical products
Cloud point extraction
Micellar solutions
UHPLC
Water samples
Microextraction
Issue Date: 2015
Publisher: 0269-3879
Project: Desarrollo de Nuevas Estrategias de Extracción en El Análisis de Residuos Farmacéuticos.Implementación en Muestras Reales de Interés Medioambiental. 
Journal: Biomedical Chromatography 
Abstract: A dispersive liquid–liquid micellar microextraction (DLLMME) method coupled with ultra‐high‐performance liquid chromatography (UHPLC) using Diode Array Detector (DAD) detector was developed for the analysis of five pharmaceutical compounds of different nature in wastewaters. A micellar solution of a surfactant, polidocanol, as extraction solvent (100 μL) and chloroform as dispersive solvent (200 μL) were used to extract and preconcentrate the target analytes. Samples were heated above critical temperature and the cloudy solution was centrifuged. After removing the chloroform, the reduced volume of surfactant was then injected in the UHPLC system. In order to obtain high extraction efficiency, the parameters affecting the liquid‐phase microextraction, such as time and temperature extraction, ionic strength and surfactant and organic solvent volume, were optimized using an experimental design. Under the optimized conditions, this procedure allows enrichment factors of up to 47‐fold. The detection limit of the method ranged from 0.1 to 2.0 µg/L for the different pharmaceuticals. Relative standard deviations were <26% for all compounds. The procedure was applied to samples from final effluent collected from wastewater treatment plants in Las Palmas de Gran Canaria (Spain), and two compounds were measured at 67 and 113 µg/L in one of them. Copyright © 2014 John Wiley & Sons, Ltd.
URI: http://hdl.handle.net/10553/47122
ISSN: 0269-3879
DOI: 10.1002/bmc.3282
Source: Biomedical Chromatography [ISSN 0269-3879], v. 29, p. 353-356
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