Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46956
Title: Mitochondrial DNA haplogroup phylogeny of the dog: Proposal for a cladistic nomenclature
Authors: Fregel, Rosa
Suárez, Nicolás M.
Betancor, Eva 
González, Ana M.
Cabrera, Vicente M.
Pestano, Jose 
Keywords: Domestic Dog
Village Dogs
D-Loop
Canis
Polymorphisms, et al
Issue Date: 2015
Publisher: 1567-7249
Journal: Mitochondrion 
Abstract: Canis lupus familiaris mitochondrial DNA analysis has increased in recent years, not only for the purpose of deciphering dog domestication but also for forensic genetic studies or breed characterization. The resultant accumulation of data has increased the need for a normalized and phylogenetic-based nomenclature like those provided for human maternal lineages. Although a standardized classification has been proposed, haplotype names within clades have been assigned gradually without considering the evolutionary history of dog mtDNA. Moreover, this classification is based only on the D-loop region, proven to be insufficient for phylogenetic purposes due to its high number of recurrent mutations and the lack of relevant information present in the coding region.In this study, we design 1) a refined mtDNA cladistic nomenclature from a phylogenetic tree based on complete sequences, classifying dog maternal lineages into haplogroups defined by specific diagnostic mutations, and 2) a coding region SNP analysis that allows a more accurate classification into haplogroups when combined with D-loop sequencing, thus improving the phylogenetic information obtained in dog mitochondrial DNA studies. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
URI: http://hdl.handle.net/10553/46956
ISSN: 1567-7249
DOI: 10.1016/j.mito.2015.04.001
Source: Mitochondrion[ISSN 1567-7249],v. 22, p. 75-84
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