Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46954
Title: Mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from canine infections
Authors: Tejedor Junco, María Teresa 
Martín Barrasa, José Luis 
Navia de Roux, Margarita María
Freixes, Joan
Vila Estapé, Jordi
UNESCO Clasification: 240111 Patología animal
310907 Patología
240118 Mamíferos
Keywords: Escherichia-Coli
Gyra Mutations
Efflux Pumps
Ciprofloxacin
Parc, et al
Issue Date: 2003
Publisher: 0378-1135
Journal: Veterinary Microbiology 
Abstract: Chronic otitis externa in dogs is often associated with Pseudomonas aeruginosa infection. Fluoroquinolones are often used for treating such infections. Fluoroquinolone resistance mechanisms were characterized in 10 strains of P aeruginosa isolated from chronic canine otitis externa. Nine out of ten strains harbored a mutation in the gyrA gene and presented an overexpression of efflux pump(s). There was a good correlation between the lipophilicity of the fluoroquinolone being tested and the effect of the efflux pump inhibitor in the final MIC. Therefore, both mechanisms, mutation in the gyrA gene and increased efflux pump(s), seem to play an important role in the acquisition of fluoroquinolone resistance in veterinary clinical isolates of P. aeruginosa. Levels of resistance to fluoroquinolones suggest that they could not be a good choice for systemic therapy of Pseudomonas otitis.
URI: http://hdl.handle.net/10553/46954
ISSN: 0378-1135
DOI: 10.1016/S0378-1135(03)00129-9
Source: Veterinary Microbiology [ISSN 0378-1135], v. 94, p. 295-301
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