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http://hdl.handle.net/10553/46790
Title: | Potential implications of the choice among three alternative treatment targets for apolipoprotein B100 in the management of patients with type 2 diabetes and chronic kidney disease | Authors: | Boronat, Mauro García-Cantón, César López-Ríos, Laura Quevedo, Virginia Lorenzo, Dionisio L. Batista, Fátima Riaño, Marta Nóvoa, Francisco J. |
UNESCO Clasification: | 32 Ciencias médicas 3205 Medicina interna |
Keywords: | Apolipoprotein B100, Low-density lipoprotein–cholesterol Non-high-density lipoprotein–cholesterol Cardiovascular risk Lipid goals, et al |
Issue Date: | 2014 | Journal: | Diabetes and Vascular Disease Research | Abstract: | This study analyses discordance rates between attainment of therapeutic goals for apolipoprotein B100 (apoB) and both low-density lipoprotein-cholesterol (LDL-C) and non-high-density lipoprotein-cholesterol (non-HDL-C) in a sample of 152 patients with type 2 diabetes and chronic kidney disease from Gran Canaria (Spain), using treatment targets recommended by the American Diabetes Association/American College of Cardiology (ADA/ACC), the European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) and by a Spanish population-based study. Among subjects with LDL-C levels at therapeutic goal, apoB was above target in 16.3% (ADA/ACC), 6.5% (ESC/EAS) and 39.1% (population-based criteria), and among subjects with non-HDL-C levels at therapeutic goal, apoB was above target in 10.5% (ADA/ACC), 1.2% (ESC/EAS) and 29.6% (population-based criteria). These findings show that clinical management would be very differently altered depending on the criteria used to set treatment targets for apoB. Cut-off points derived from population data identify a greater number of subjects suitable for a more intensive lipid-lowering therapy. | URI: | http://hdl.handle.net/10553/46790 | ISSN: | 1479-1641 | DOI: | 10.1177/1479164113511834 | Source: | Diabetes and Vascular Disease Research [ISSN 1479-1641],v. 11, p. 53-59 |
Appears in Collections: | Artículos |
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