Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46789
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dc.contributor.authorSánchez-Hernández, Rosa M.
dc.contributor.authorGarcía-Cantón, César
dc.contributor.authorLorenzo, Dionisio L.
dc.contributor.authorVirginia, Quevedo
dc.contributor.authorBosch, Elvira
dc.contributor.authorLópez-Ríos, Laura
dc.contributor.authorRiaño, Marta
dc.contributor.authorBoronat, Mauro
dc.date.accessioned2018-11-23T08:12:28Z-
dc.date.available2018-11-23T08:12:28Z-
dc.date.issued2015
dc.identifier.issn0301-0430
dc.identifier.urihttp://hdl.handle.net/10553/46789-
dc.description.abstractAims: Vitamin D deficiency is highly prevalent in subjects with advanced chronic kidney disease (CKD), but diabetes, the most common cause of CKD, has also been linked to low levels of serum 25-hydroxyvitamin D [25(OH) D]. We compare vitamin D status between subjects with type 2 diabetes-related advanced CKD and subjects with either advanced CKD without diabetes or type 2 diabetes without advanced CKD. Methods: Subjects were patients with advanced CKD (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m(2)) from February 2011 to November 2013 (113 with diabetes-related CKD and 80 without diabetes) and 61 patients with long-lasting type 2 diabetes without advanced CKD, simultaneously enrolled from our center. Participants fulfilled a survey questionnaire and underwent physical examination, blood samples, and 24-h urine collection. Kidney disease was assessed using eGFR and 24-h urinary protein excretion. Serum 25(OH) D was measured by chemiluminescence immunoassay. Results: The prevalence of vitamin D deficiency (25(OH) D < 20 ng/mL) was 70.8% in subjects with diabetes-related CKD, 38.8% in subjects with non-diabetic CKD and 41% in subjects with diabetes without advanced CKD. Adjusted means (95% confidence interval (CI)) of 25(OH) D in participants with diabetes-related CKD, in nondiabetic participants with CKD, and in participants with diabetes without advanced CKD were, respectively, 17.5 (14.2 - 20.7), 23.6 (19.4 - 27.8), and 23.5 (16.8 - 30.3) ng/mL (p = 0.023). Conclusions: Low vitamin D status is characteristically associated with advanced diabetic nephropathy. This relationship is not entirely attributable to the individual effects of CKD or long-lasting diabetes.
dc.publisher0301-0430
dc.relation.ispartofClinical Nephrology
dc.sourceClinical Nephrology[ISSN 0301-0430],v. 83, p. 218-224
dc.subject.other25-Hydroxyvitamin D Levels
dc.subject.other3Rd National-Health
dc.subject.otherEnhanced Excretion
dc.subject.otherAssociation
dc.subject.otherMegalin
dc.titleThe specific relationship between vitamin D deficiency and diabetic nephropathy among patients with advanced chronic kidney disease: A cross-sectional study in Gran Canaria, Spain
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.5414/CN108446
dc.identifier.scopus84933043064-
dc.identifier.isi000352238000003
dc.contributor.authorscopusid57203232814
dc.contributor.authorscopusid6603127359
dc.contributor.authorscopusid55967938300
dc.contributor.authorscopusid57188624099
dc.contributor.authorscopusid36027905600
dc.contributor.authorscopusid33068166900
dc.contributor.authorscopusid37067926100
dc.contributor.authorscopusid7003952293
dc.description.lastpage224
dc.description.firstpage218
dc.relation.volume83
dc.type2Artículoes
dc.contributor.daisngid3858758
dc.contributor.daisngid1915819
dc.contributor.daisngid30519221
dc.contributor.daisngid5112593
dc.contributor.daisngid1780664
dc.contributor.daisngid1964185
dc.contributor.daisngid5257474
dc.contributor.daisngid673494
dc.contributor.wosstandardWOS:Sanchez-Hernandez, RM
dc.contributor.wosstandardWOS:Garcia-Canton, C
dc.contributor.wosstandardWOS:Lorenzo, DL
dc.contributor.wosstandardWOS:Quevedo, V
dc.contributor.wosstandardWOS:Bosch, E
dc.contributor.wosstandardWOS:Lopez-Rios, L
dc.contributor.wosstandardWOS:Riano, M
dc.contributor.wosstandardWOS:Boronat, M
dc.date.coverdateAbril 2015
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDiabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-5988-8222-
crisitem.author.orcid0000-0001-8535-8543-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGarcía Cantón, César-
crisitem.author.fullNameLorenzo Villegas, Dionisio Lorenzo-
crisitem.author.fullNameBoronat Cortés, Mauro-
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