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Title: Relationships between characteristics of exposure to pigeon antigens: Clinical manifestations and humoral immune response
Authors: De Castro, F. R. 
Carrillo, T. 
Castillo, R.
Blanco, C.
Diaz, F.
Cuevas, M.
UNESCO Clasification: 32 Ciencias médicas
320701 Alergias
320710 Inmunopatología
Keywords: Extrinsic Allergic Alveolitis
Hypersensitivity Pneumonitis
Breeders Disease
Avian Exposure
Fanciers Lung, et al
Issue Date: 1993
Journal: Chest (American College of Chest Physicians) 
Abstract: An extensive clinical study has been performed on pigeon breeders in the Canary Islands. Three hundred forty-three subjects have participated in this study through the filling of a clinical and epidemiologic questionnaire. A venous blood sample was also taken from each fancier for a further serologic analysis. Detection of specific IgG antibodies was made by an indirect enzyme-linked immunosorbent assay (ELISA) using pigeon serum as antigenic material. Twenty-nine (8 percent) breeders fulfilled the ''classic'' pigeon breeders' disease (PBD) criteria. One hundred six (31 percent) bad rhinitis, 62 (19 percent) had immediate bronchial symptoms, and 51 (15 percent) suffered from chronic bronchitis. A significant level of specific IgG was detected in 139 (40 percent) cases. Rates were correlated with pneumonitis symptomatology (p<0.001) and with chronic bronchitis (p<0.05). There was a significant association between the number of pigeons and the level of sensitization (p<0.001). Finally, a statistical relationship between the intensity of exposure and specific IgG response was also found (p<0.001). Titers of specific IgE could not be related either to the reported symptomatology in the questionnaire or to any of the exposure parameters analyzed.
ISSN: 0012-3692
DOI: 10.1378/chest.103.4.1059
Source: Chest[ISSN 0012-3692],v. 103 (4), p. 1059-1063
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