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Title: Association of HLA-DR11 with the anaphylactoid reaction caused by nonsteroidal anti-inflammatory drugs
Authors: Quiralte, Joaquin
Sánchez-García, Florentine
Torres, María José
Blanco, Carlos
Castillo, Rodolfo
Ortega, Nancy
Rodríguez De Castro, Felipe 
Pérez-Aciego, Paloma
Carrillo, Teresa 
UNESCO Clasification: 32 Ciencias médicas
320701 Alergias
Keywords: HLA
NSAID sensitivity
Anaphylactoid reaction
Issue Date: 1999
Journal: Journal of Allergy and Clinical Immunology 
Abstract: Background: Several HLA alleles have been associated with asthma induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The existence of HLA markers linked to other NSAID-induced reactions, such as cutaneous and anaphylactoid reactions, has not been established. Objective: The purpose of our work was to study the HLA-DRB1 and HLA-DQB1 alleles in patients with cutaneous and anaphylactoid reactions caused by NSAIDs. Methods: We have analyzed 114 HLA DRB1 and 26 HLA-DQB1 alleles in 21 patients with anaphylactoid reactions caused by NSAIDs, 47 patients who had exclusively cutaneous reactions during single-blind, placebo-controlled oral challenges with NSAIDs, and 167 tolerant control subjects (29 of whom had also had an IgE-mediated anaphylaxis to different agents). HLA-DRB1 and HLA-DQB1 alleles were typed by the polymerase chain reaction sequence-specific primers method with genomic DNA. Results: The frequency of HLA-DR11 alleles was 58.8% in the anaphylactoid reaction group, compared with 15.9% in the NSAID-tolerant healthy control subjects (OR, 7:3; 95% confidence interval, 2.8-19.0; P < .02) and 6.3% in the group of the patients with a tolerance for NSAIDs and with IgE-mediated anaphylaxis (OR, 18.75; 95% confidence interval, 4.3-81.1; P < .004). No differences were observed among HLA-DR11 alleles analyzed. There were no significant HLA-DQB1 associations with NSAID-induced anaphylactoid reactions. Patients with cutaneous reactions had HLA frequencies that did not differ significantly from the tolerant control subjects. Conclusion: The HLA-DRB1*11 alleles showed a positive association with NSAID-induced anaphylactoid reactions.
ISSN: 0091-6749
DOI: 10.1016/S0091-6749(99)70243-5
Source: Journal of Allergy and Clinical Immunology[ISSN 0091-6749],v. 103, p. 685-689
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