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Title: | Variants at the promoter of the interleukin-6 gene are associated with severity and outcome of pneumococcal community-acquired pneumonia | Authors: | Martín-Loeches, Ignacio Solé-Violán, Jordi Rodríguez De Castro, Felipe García-Laorden, M. Isabel Borderías, Luis Blanquer, José Rajas, Olga Briones, M. Luisa Aspa, Javier Herrera-Ramos, Estefanía Marcos-Ramos, José Alberto Sologuren, Ithaisa González-Quevedo, Nereida Ferrer-Agüero, José María Noda, Judith Rodríguez-Gallego, Carlos |
UNESCO Clasification: | 32 Ciencias médicas 320508 Enfermedades pulmonares 320102 Genética clínica |
Keywords: | C-Reactive Protein Streptococcus-Pneumoniae Coronary Revascularization Inflammatory Response Sepsis, et al |
Issue Date: | 2012 | Journal: | Intensive Care Medicine | Abstract: | Conflicting results about the role of genetic variability at IL6, particularly the -174 G/C single nucleotide polymorphism (SNP), in sepsis have been reported. We studied the genetic variability at IL6 in patients with community-acquired pneumonia (CAP) and pneumococcal CAP (P-CAP).This was a multicenter, prospective observational study. IL6 -174 was analyzed in 1,227 white Spanish patients with CAP (306 with P-CAP). IL6 1753 C/G (N = 750), 2954 G/C (N = 845), and haplotypes defined by these SNPs were also studied.In CAP patients the genotype -174 GG were associated with protection against acute respiratory distress syndrome (ARDS) (p = 0.008, OR = 0.4, 95% CI 0.2-0.8). No other significant associations were observed. However, in patients with P-CAP multivariate analysis adjusted for age, gender, co-morbidity, hospital of origin, and severity (pneumonia severity index, PSI) showed that the IL6 -174 GG genotype was protective against the development of ARDS (p = 0.002, OR = 0.25, 95% CI 0.07-0.79), septic shock (p = 0.006, OR = 0.46, 95% CI 0.18-0.79), and multiple organ dysfunction syndrome (p = 0.02, OR = 0.53, 95% CI 0.27-0.89). P-CAP patients homozygous for IL6 -174 G also showed a higher survival in a logistic regression analysis adjusted for age, gender, co-morbidity, hospital of origin, and PSI (p = 0.048, OR = 0.27, 95% CI 0.07-0.98).Our results indicate that the IL-6 -174 GG genotype is associated with lower severity and mortality in patients with P-CAP. This effect was higher than that observed in patients with CAP irrespective of the causal pathogen involved. Our results highlight the importance of the causal pathogen in genetic epidemiological studies in sepsis. | URI: | http://hdl.handle.net/10553/46583 | ISSN: | 0342-4642 | DOI: | 10.1007/s00134-011-2406-y | Source: | Intensive Care Medicine [ISSN 0342-4642], v. 38, p. 256-262 |
Appears in Collections: | Artículos |
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