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Title: Usefulness of the "candida score" for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: A prospective multicenter study
Authors: León, Cristóbal
Ruiz-Santana, Sergio 
Saavedra, Pedro
Galván, Beatriz
Blanco, Armando
Castro, Carmen
Balasini, Carina
Utande-Vázquez, Aránzazu
González De Molina, Francisco J.
Blasco-Navalproto, Miguel A.
López, Maria J.
Charles, Pierre Emmanuel
Martín, Estrella
Hernández-Viera, María Adela
UNESCO Clasification: 32 Ciencias médicas
320505 Enfermedades infecciosas
Keywords: Intensive-Care-Unit
Antifungal Prophylaxis, et al
Issue Date: 2009
Journal: Critical Care Medicine 
Conference: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy 
Abstract: Objective: To assess the usefulness of the "Candida score" (CS) for discriminating between Candida species colonization and invasive candidiasis (IC) in non-neutropenic critically ill patients. A rate of IC <5% in patents with CS <3 was the primary end point.Design: Prospective, cohort, observational study.Patients: A total of 1,107 non-neutropenic adult intensive care unit patients admitted for at least 7 days between April 2006 and June 2007.Measurements and Main Results: Clinical data, surveillance cultures for fungal growth, and serum levels of (1-3)-beta-D-glucan and anti-Candida antibodies (in a subset of patients) were recorded. The CS was calculated as follows (variables coded as absent = 0, present = 1): total parenteral nutrition x 1, plus surgery x 1, plus multifocal Candida colonization x 1, plus severe sepsis x 2. A CS >= 3 accurately selected patients at high risk for IC. The colonization index was registered if >= 0.5. The rate of IC was 2.3% (95% confidence interval [CI] 1.06-3.54) among patients with CS <3, with a linear association between increasing values of CS and IC rate (p <= 0.001). The area under the receiver operating characteristic curve for CS was 0.774 (95% CI 0.715-0.832) compared with 0.633 (95% CI 0.557-0.709) for CI. (1-3)-Beta-D-glucan was also an independent predictor of IC (odds ratio 1.004, 95% CI 1.0-1.007). The relative risk for developing IC in colonized patients without antifungal treatment was 6.83 (95% CI 3.81-12.45).Conclusions: In this cohort of colonized patients staying >7 days, with a CS <3 and not receiving antifungal treatment, the rate of IC was <5%. Therefore, IC is highly improbable if a Candida-colonized non-neutropenic critically ill patient has a CS <3.
ISSN: 0090-3493
DOI: 10.1097/CCM.0b013e31819daa14
Source: Critical Care Medicine [ISSN 0090-3493],v. 37, p. 1624-1633
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