Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45939
Título: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions
Autores/as: León, Cristóbal
Ruiz-Santana, Sergio
Saavedra, Pedro
Castro, Carmen
Loza, Ana
Zakariya, Ismail
Úbeda, Alejandro
Parra, Manuel
Macías, Desirée
Tomás, José Ignacio
Rezusta, Antonio
Rodríguez, Alejandro
Gómez, Frederic
Martín-Mazuelos, Estrella
Tomás, J. I.
Gurpegui, M.
González, V.
León, C.
úbeda, A.
Macías, D.
Rodríguez, A.
Bodi, M.
Gómez, F.
Trefler, S.
Llauradó, M.
Güell, R.
González, R.
Díaz, F. J.
González, Raúl
Marcos, J. M.
Carriedo, D.
Fernández, I.
Valverde, E.
Esteban, A.
Marrodan, T.
Arenzana, A.
González, C.
Suárez, A. I.
Ballús, J.
Esteve, F.
Ayats, J.
Aguilar, G.
Badenes, R.
Ferrando, C.
Navarro, D.
Carbonell, J. A.
García, C.
Gómez, A.
Henao, L.
Miñana, A.
Puig, J.
Belda, F. J.
Puppo, A.
Garnacho, J.
Márquez, J. A.
Gutiérrez, A.
Ruiz, M.
Jeréz, V.
Trasmonte, V.
Martínez, P.
Pérez, D.
Fajardo, M.
Gaona, C.
Muñoz, C.
Tamayo, G.
Martínez, A.
Labayen, F.
Iruretagoyena, J. R.
López, L.
Hernández, J. L.
Ruiz-Santana, S. 
Hernández, M. A.
Bordes, A.
Ojeda, N.
Jiménez, J. D.
Clasificación UNESCO: 32 Ciencias médicas
3201 Ciencias clínicas
Palabras clave: Critically-Ill Patients
Beta-D-Glucan
Germ Tube Antibody
Fungal-Infections
Intraabdominal Candidiasis, et al.
Fecha de publicación: 2016
Publicación seriada: Critical Care 
Resumen: Background: To assess the performance of Candida albicans germ tube antibody (CAGTA), (1 -> 3)-beta-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and Candida DNA for diagnosing invasive candidiasis (IC) in ICU patients with severe abdominal conditions (SAC).Methods: A prospective study of 233 non-neutropenic patients with SAC on ICU admission and expected stay >= 7 days. CAGTA (cutoff positivity >= 1/160), BDG (>= 80, 100 and 200 pg/mL), mannan-Ag (>= 60 pg/mL), mannan-Ab (>= 10 UA/mL) were measured twice a week, and Candida DNA only in patients treated with systemic antifungals. IC diagnosis required positivities of two biomarkers in a single sample or positivities of any biomarker in two consecutive samples. Patients were classified as neither colonized nor infected (n = 48), Candida spp. colonization (n = 154) (low-grade, n = 130; high-grade, n = 24), and IC (n = 31) (intra-abdominal candidiasis, n = 20; candidemia, n = 11).Results: The combination of CAGTA and BDG positivities in a single sample or at least one of the two biomarkers positive in two consecutive samples showed 90.3 % (95 % CI 74.2-98.0) sensitivity, 42.1 % (95 % CI 35.2-98.8) specificity, and 96.6 % (95 % CI 90.5-98.8) negative predictive value. BDG positivities in two consecutive samples had 76.7 % (95 % CI 57.7-90.1) sensitivity and 57.2 % (95 % CI 49.9-64.3) specificity. Mannan-Ag, mannan-Ab, and Candida DNA individually or combined showed a low discriminating capacity.Conclusions: Positive Candida albicans germ tube antibody and (1 -> 3)-beta-D-glucan in a single blood sample or (1 -> 3)-beta-D-glucan positivity in two consecutive blood samples allowed discriminating invasive candidiasis from Candida spp. colonization in critically ill patients with severe abdominal conditions. These findings may be helpful to tailor empirical antifungal therapy in this patient population.
URI: http://hdl.handle.net/10553/45939
ISSN: 1364-8535
DOI: 10.1186/S13054-016-1324-3
Fuente: Critical Care [ISSN 1364-8535], v. 20 (149)
Colección:Artículos
Vista completa

Citas SCOPUSTM   

78
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

70
actualizado el 25-feb-2024

Visitas

58
actualizado el 09-jul-2022

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.