Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45939
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dc.contributor.authorLeón, Cristóbalen_US
dc.contributor.authorRuiz-Santana, Sergioen_US
dc.contributor.authorSaavedra, Pedroen_US
dc.contributor.authorCastro, Carmenen_US
dc.contributor.authorLoza, Anaen_US
dc.contributor.authorZakariya, Ismailen_US
dc.contributor.authorÚbeda, Alejandroen_US
dc.contributor.authorParra, Manuelen_US
dc.contributor.authorMacías, Desiréeen_US
dc.contributor.authorTomás, José Ignacioen_US
dc.contributor.authorRezusta, Antonioen_US
dc.contributor.authorRodríguez, Alejandroen_US
dc.contributor.authorGómez, Fredericen_US
dc.contributor.authorMartín-Mazuelos, Estrellaen_US
dc.contributor.authorTomás, J. I.en_US
dc.contributor.authorGurpegui, M.en_US
dc.contributor.authorGonzález, V.en_US
dc.contributor.authorLeón, C.en_US
dc.contributor.authorúbeda, A.en_US
dc.contributor.authorMacías, D.en_US
dc.contributor.authorRodríguez, A.en_US
dc.contributor.authorBodi, M.en_US
dc.contributor.authorGómez, F.en_US
dc.contributor.authorTrefler, S.en_US
dc.contributor.authorLlauradó, M.en_US
dc.contributor.authorGüell, R.en_US
dc.contributor.authorGonzález, R.en_US
dc.contributor.authorDíaz, F. J.en_US
dc.contributor.authorGonzález, Raúlen_US
dc.contributor.authorMarcos, J. M.en_US
dc.contributor.authorCarriedo, D.en_US
dc.contributor.authorFernández, I.en_US
dc.contributor.authorValverde, E.en_US
dc.contributor.authorEsteban, A.en_US
dc.contributor.authorMarrodan, T.en_US
dc.contributor.authorArenzana, A.en_US
dc.contributor.authorGonzález, C.en_US
dc.contributor.authorSuárez, A. I.en_US
dc.contributor.authorBallús, J.en_US
dc.contributor.authorEsteve, F.en_US
dc.contributor.authorAyats, J.en_US
dc.contributor.authorAguilar, G.en_US
dc.contributor.authorBadenes, R.en_US
dc.contributor.authorFerrando, C.en_US
dc.contributor.authorNavarro, D.en_US
dc.contributor.authorCarbonell, J. A.en_US
dc.contributor.authorGarcía, C.en_US
dc.contributor.authorGómez, A.en_US
dc.contributor.authorHenao, L.en_US
dc.contributor.authorMiñana, A.en_US
dc.contributor.authorPuig, J.en_US
dc.contributor.authorBelda, F. J.en_US
dc.contributor.authorPuppo, A.en_US
dc.contributor.authorGarnacho, J.en_US
dc.contributor.authorMárquez, J. A.en_US
dc.contributor.authorGutiérrez, A.en_US
dc.contributor.authorRuiz, M.en_US
dc.contributor.authorJeréz, V.en_US
dc.contributor.authorTrasmonte, V.en_US
dc.contributor.authorMartínez, P.en_US
dc.contributor.authorPérez, D.en_US
dc.contributor.authorFajardo, M.en_US
dc.contributor.authorGaona, C.en_US
dc.contributor.authorMuñoz, C.en_US
dc.contributor.authorTamayo, G.en_US
dc.contributor.authorMartínez, A.en_US
dc.contributor.authorLabayen, F.en_US
dc.contributor.authorIruretagoyena, J. R.en_US
dc.contributor.authorLópez, L.en_US
dc.contributor.authorHernández, J. L.en_US
dc.contributor.authorRuiz-Santana, S.en_US
dc.contributor.authorHernández, M. A.en_US
dc.contributor.authorBordes, A.en_US
dc.contributor.authorOjeda, N.en_US
dc.contributor.authorJiménez, J. D.en_US
dc.date.accessioned2018-11-23T00:02:28Z-
dc.date.available2018-11-23T00:02:28Z-
dc.date.issued2016en_US
dc.identifier.issn1364-8535en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/45939-
dc.description.abstractBackground: To assess the performance of Candida albicans germ tube antibody (CAGTA), (1 -> 3)-beta-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and Candida DNA for diagnosing invasive candidiasis (IC) in ICU patients with severe abdominal conditions (SAC).Methods: A prospective study of 233 non-neutropenic patients with SAC on ICU admission and expected stay >= 7 days. CAGTA (cutoff positivity >= 1/160), BDG (>= 80, 100 and 200 pg/mL), mannan-Ag (>= 60 pg/mL), mannan-Ab (>= 10 UA/mL) were measured twice a week, and Candida DNA only in patients treated with systemic antifungals. IC diagnosis required positivities of two biomarkers in a single sample or positivities of any biomarker in two consecutive samples. Patients were classified as neither colonized nor infected (n = 48), Candida spp. colonization (n = 154) (low-grade, n = 130; high-grade, n = 24), and IC (n = 31) (intra-abdominal candidiasis, n = 20; candidemia, n = 11).Results: The combination of CAGTA and BDG positivities in a single sample or at least one of the two biomarkers positive in two consecutive samples showed 90.3 % (95 % CI 74.2-98.0) sensitivity, 42.1 % (95 % CI 35.2-98.8) specificity, and 96.6 % (95 % CI 90.5-98.8) negative predictive value. BDG positivities in two consecutive samples had 76.7 % (95 % CI 57.7-90.1) sensitivity and 57.2 % (95 % CI 49.9-64.3) specificity. Mannan-Ag, mannan-Ab, and Candida DNA individually or combined showed a low discriminating capacity.Conclusions: Positive Candida albicans germ tube antibody and (1 -> 3)-beta-D-glucan in a single blood sample or (1 -> 3)-beta-D-glucan positivity in two consecutive blood samples allowed discriminating invasive candidiasis from Candida spp. colonization in critically ill patients with severe abdominal conditions. These findings may be helpful to tailor empirical antifungal therapy in this patient population.en_US
dc.languageengen_US
dc.relation.ispartofCritical Careen_US
dc.sourceCritical Care [ISSN 1364-8535], v. 20 (149)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3201 Ciencias clínicasen_US
dc.subject.otherCritically-Ill Patientsen_US
dc.subject.otherBeta-D-Glucanen_US
dc.subject.otherGerm Tube Antibodyen_US
dc.subject.otherFungal-Infectionsen_US
dc.subject.otherIntraabdominal Candidiasisen_US
dc.subject.otherNonculture Diagnosticsen_US
dc.subject.otherAntifungal Stewardshipen_US
dc.subject.otherPotential Roleen_US
dc.subject.otherColonizationen_US
dc.subject.otherManagementen_US
dc.subject.otherInvasive Candidiasisen_US
dc.subject.otherCandida Spp. Colonizationen_US
dc.subject.other(1 -> 3)-Beta-D-Glucanen_US
dc.subject.otherCandida Albicans Germ Tube Antibodyen_US
dc.subject.otherMannan Antigenen_US
dc.subject.otherAnti-Mannan Antibodyen_US
dc.subject.otherCandida Pcren_US
dc.subject.otherIntra-Abdominal Candidiasisen_US
dc.subject.otherCandidemiaen_US
dc.titleContribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditionsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/S13054-016-1324-3en_US
dc.identifier.scopus85008600459-
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dc.identifier.eissn1364-8535-
dc.identifier.issue149-
dc.relation.volume20en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
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dc.description.numberofpages14en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Leon, C-
dc.contributor.wosstandardWOS:Ruiz-Santana, S-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:Castro, C-
dc.contributor.wosstandardWOS:Loza, A-
dc.contributor.wosstandardWOS:Zakariya, I-
dc.contributor.wosstandardWOS:Ubeda, A-
dc.contributor.wosstandardWOS:Parra, M-
dc.contributor.wosstandardWOS:Macias, D-
dc.contributor.wosstandardWOS:Tomas, JI-
dc.contributor.wosstandardWOS:Rezusta, A-
dc.contributor.wosstandardWOS:Rodriguez, A-
dc.contributor.wosstandardWOS:Gomez, F-
dc.contributor.wosstandardWOS:Martin-Mazuelos, E-
dc.date.coverdateEnero 2016en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr5,358
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGrupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-3927-3236-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRuiz Santana, Sergio-
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