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Title: Immunoprotection in goats against Haemonchus contortus after immunization with cysteine protease enriched protein fractions
Authors: Ruiz, Antonio
Molina Caballero, José Manuel 
González, Jorge Francisco 
Conde, Magnolia María
Martín, Sergio 
Hernández, Yeray Isidro
Keywords: Anthelmintic Resistance
Protective Immunity
Adult Worms
Nematode, et al
Issue Date: 2004
Publisher: 0928-4249
Journal: Veterinary Research 
Abstract: Haemonchus cysteine proteases, because of their apparent critical function in worm physiology, are considered important candidates in the immunological control of haemonchosis in sheep. Only limited information is, however, available on the immuntoprotective properties of these molecules in goats. In the present study cysteine proteases of Haemonchus contortus adult worms isolated from a goat strain (Gran Canaria, Spain) were enriched by affinity chromatography and evaluated as immunoprotective antigens against caprine haemonchosis. The eggs per gram of faeces averaged over the whole experiment for unvaccinated goats (550 +/- 13.5) was significantly greater (P < 0.001) than that of vaccinated goats (61 +/- 2.9). Accordingly, the worm burden was significantly different between the groups (P < 0.05), with mean values of 247.5 +/- 43.8 and 762.5 +/- 78.3 worms per animal in the immunized and nonimmunized goats, respectively. The percentage of egg (89%) and worm (68%) reduction approached those attained with other immunogens used in sheep.
ISSN: 0928-4249
DOI: 10.1051/vetres:2004032
Source: Veterinary Research[ISSN 0928-4249],v. 35, p. 565-572
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