Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45840
Title: Evaluation of a low-dose synthetic adrenocorticotropic hormone stimulation test in clinically normal dogs and dogs with naturally developing hyperadrenocorticism
Authors: Kerl, Marie E.
Peterson, Mark E.
Wallace, Melissa S.
Melián Limiñana, Carlos 
Kemppainen, Robert James
UNESCO Clasification: 310908 Farmacología
240118 Mamíferos
Keywords: Familial Hypoadrenocorticism
Adrenal Cortex Hyperfunction
Trilostane
Animal experiment
Corticotropin, et al
Issue Date: 1999
Publisher: 0003-1488
Journal: Journal of the American Veterinary Medical Association 
Abstract: Objective: To determine whether low doses of synthetic ACTH could induce a maximal cortisol response in clinically normal dogs and to compare a low-dose ACTH stimulation protocol to a standard high-dose ACTH stimulation protocol in dogs with hyperadrenocorticism. Design: Cohort study. Animals: 6 clinically normal dogs and 7 dogs with hyperadrenocorticism. Procedure: Each clinically normal dog was given 1 of 3 doses of cosyntropin (1, 5, or 10 micrograms/kg [0.45, 2.3, or 4.5 micrograms/lb] of body weight, i.v.) in random order at 2-week intervals. Samples for determination of plasma cortisol and ACTH concentrations were obtained before and 30, 60, 90, and 120 minutes after ACTH administration. Each dog with hyperadrenocorticism was given 2 doses of cosyntropin (5 micrograms/kg or 250 micrograms/dog) in random order at 2-week intervals. In these dogs, samples for determination of plasma cortisol concentrations were obtained before and 60 minutes after ACTH administration. Results: In the clinically normal dogs, peak cortisol concentration and area under the plasma cortisol response curve did not differ significantly among the 3 doses. However, mean plasma cortisol concentration in dogs given 1 microgram/kg peaked at 60 minutes, whereas dogs given doses of 5 or 10 micrograms/kg had peak cortisol values at 90 minutes. In dogs with hyperadrenocorticism, significant differences were not detected between cortisol concentrations after administration of the low or high dose of cosyntropin. Clinical implications: Administration of cosyntropin at a rate of 5 micrograms/kg resulted in maximal stimulation of the adrenal cortex in clinically normal dogs and dogs with hyperadrenocorticism.
URI: http://hdl.handle.net/10553/45840
ISSN: 0003-1488
Source: Journal of the American Veterinary Medical Association [ISSN 0003-1488], v. 214 (10), p. 1497-1501
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

41
checked on Aug 1, 2021

Page view(s)

21
checked on Jul 17, 2021

Google ScholarTM

Check


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.