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Title: Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism
Authors: Pérez Alenza, Dolores
Arenas, Carolina
Lopez, Mari Luz
Melián Limiñana, Carlos 
UNESCO Clasification: 310907 Patología
Keywords: Trilostane
Issue Date: 2006
Publisher: 1547-3317
Journal: Journal of the American Animal Hospital Association 
Abstract: Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.
ISSN: 1547-3317
DOI: 10.5326/0420269
Source: Journal of the American Animal Hospital Association [ISSN 1547-3317], v. 42, p. 269-276
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