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Title: Five-year survival and prognostic factors in a cohort of hospitalized nonagenarians
Authors: Conde-Martel, Alicia 
Hemmersbach-Miller, Marion
Marchena-Gomez, Joaquin 
Saavedra Santana, Pedro 
Betancor-Leon, Pedro
UNESCO Clasification: 32 Ciencias médicas
3205 Medicina interna
Keywords: Mini-Nutritional Assessment
Long-Term Survival
Cognitive Impairment
Postdischarge Mortality
Heart-Failure, et al
Issue Date: 2012
Journal: European Journal of Internal Medicine 
Abstract: Background: The number of hospitalized nonagenarians is increasing. Only a few studies have evaluated long-term predictors of survival in these patients. The aim of this study was to determine the 5-year outcome of a cohort of hospitalized nonagenarians, and to identify predictors of long-term survival.Methods: In 124 consecutive medical hospitalized patients older than 89 years, and followed up during 5 years, the following variables were prospectively recorded: sociodemographic characteristics, main diagnoses, Charlson comorbidity index, Barthel index, Lawton-Brody test, Mini-Mental State Examination, Short Portable Mental Status Questionnaire of Pfeiffer, Mini Nutritional Assessment, albumin levels, and the 5-year survival.Results: Out of the 124 patients, 109 died (87.9%) during the follow-up. The probability of being alive at 1, 3 and 5 years was 45%, 22% and 12%, respectively. A worse 5-year survival was significantly related to the diagnoses of pneumonia (p=0.037), heart failure (p=0.045), higher Charlson index (p=0.026), poorer functional status measured by the Barthel index (p=0.003), and the Lawton-Brody test (p=0.007), cognitive impairment measured by the Pfeiffer test (p=0.011), and lower levels of albumin (p=0.028). In the multivariate analysis, the Charlson index (p<0.001), and the Barthel index (p=0.003) were independently related to 5-year survival. These two variables were also 5-year survival prognostic factors in the subgroup of discharged patients. A prognostic index using these two variables was created: PI=(0.2 x Charlson index + 0.6 x Barthel index) x 0.92.Conclusions: In hospitalized nonagenarian patients, poor scores in the Barthel Index and a higher comorbidity evaluated by the Charlson index are independently related to 5-year survival.
ISSN: 0953-6205
DOI: 10.1016/j.ejim.2012.02.007
Source: European Journal of Internal Medicine [ISSN 0953-6205], v. 23, p. 513-518
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